54113-73-4Relevant articles and documents
Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer
Yu, Chao-Wu,Hung, Pei-Yun,Yang, Hui-Ting,Ho, Yi-Hsun,Lai, Hsing-Yi,Cheng, Yi-Sheng,Chern, Ji-Wang
, p. 857 - 874 (2019/01/08)
We designed and synthesized quinazolin-2,4-dione-based hydroxamic acids to serve as selective competitive inhibitors of histone deacetylase-6 (HDAC6). The most potent and selective compound, 3d (IC50, 4 nM, HDAC6; IC50 > 10 μM, HDAC1
QUINAZOLINE DERIVATIVES AS ANTIVIRAL AGENTS
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Page/Page column 28-29, (2010/11/26)
The present invention relates to the use of quinazoline derivatives of formula (I) wherein A, B, R1, R2, R3 and R4 are defined herein, and pharmaceutically acceptable salts thereof, for the treatment or preventi