54143-57-6

Basic information

• Product Name: Metoclopramide hydrochloride
• Synonyms: Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy-, monohydrochloride, monohydrate;Metoclopramide monohydrochloride monohydrate;Metoclopramide Hydrochloride (500 mg);Annavar;MetoclopraMide Hydrochloride, USP;MetoclopraMide HCI;4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide monohydrochloride monohydrate;Metoclopramide (hydrochloride hydrate)
• CAS NO: 54143-57-6
• Molecular Formula: C14H22ClN3O2.ClH
• Molecular Weight: 336.26
• EINECS: 230-634-5
• Product Categories: Steroid and Hormone;API
• Mol File: 54143-57-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 182.5-184°
• Boiling Point: 504.6 °C at 760 mmHg
• Flash Point: 259 °C
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Methanol (Slightly), Water (Slightly)
• Water Solubility: It is very soluble in water, easily soluble in ethyl alcohol, slightly soluble in dichloromethane.
• Sensitive: Light Sensitive
• CAS DataBase Reference: Metoclopramide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Metoclopramide hydrochloride(54143-57-6)
• EPA Substance Registry System: Metoclopramide hydrochloride(54143-57-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 54143-57-6(Hazardous Substances Data)

Usage

Description

Metoclopramide hydrochloride is a pharmaceutical compound with a monohydrate form, which serves as an antiemetic drug and dopamine receptor antagonist. It is commonly used for the treatment of gastrointestinal disorders and can also exhibit sedative, extrapyrimidal, and prolactin secretion stimulation actions.

Uses

Used in Pharmaceutical Industry:
Metoclopramide hydrochloride is used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and biological fluids by chromatography and chemiluminescence techniques.
Used in Medical Treatment:
Metoclopramide hydrochloride is used as an antiemetic agent for the treatment of gastrointestinal disorders, helping to alleviate symptoms such as nausea and vomiting.
Used in Dopamine Receptor Antagonism:
Metoclopramide hydrochloride is used as a dopamine receptor antagonist, which can help in managing certain conditions related to dopamine imbalances.
Used in Quality Control:
Metoclopramide hydrochloride serves as a secondary standard for application in quality control, providing a convenient and cost-effective alternative to the preparation of in-house working standards for pharmaceutical laboratories and manufacturers.

Indications

Metoclopramide (Reglan) stimulates upper GI tract motility and has both central and peripheral actions. Centrally, it is a dopamine antagonist, an action that is important both for its often desirable antiemetic effect and other less desirable effects. Peripherally, it stimulates the release of intrinsic postganglionic stores of acetylcholine and sensitizes the gastric smooth muscle to muscarinic stimulation. The ability of metoclopramide to antagonize the inhibitory neurotransmitter effect of dopamine on the GI tract results in increased gastric contraction and enhanced gastric emptying and small bowel transit.

Therapeutic Function

Antiemetic

Mechanism of action

Metoclopramide is rapidly absorbed following an oral dose in a patient with intact gastric emptying. Peak plasma concentration is achieved within 40 to 120 minutes. With normal renal function, plasma half-life is about 4 hours.About 20% of an oral dose is eliminated unchanged in the urine, while 60% is eliminated as sulfate or glucuronide conjugates.

Clinical Use

Improved gastric emptying will frequently alleviate symptoms in patients with diabetic, postoperative, or idiopathic gastroparesis. Since metoclopramide also can decrease the acid reflux into the esophagus that results from slowed gastric emptying or lower esophageal sphincter pressure, the drug can be used as an adjunct in the treatment of reflux esophagitis.

Side effects

Side effects include fatigue, insomnia, and altered motor coordination. Parkinsonian side effects and acute dystonic reactions also have been reported. Metoclopramide stimulates prolactin secretion, which can cause galactorrhea and menstrual disorders. Extrapyramidal side effects seen following administration of the phenothiazines, thioxanthenes, and butyrophenones may be accentuated by metoclopramide.