5416-67-1Relevant articles and documents
Comparison between Conventional and Nonconventional Methods for the Synthesis of Some 2-Oxazolidinone Derivatives and Preliminary Investigation of Their Inhibitory Activity Against Certain Protein Kinases
Ziane,Mazari,Safer,Sad El Hachemi Amar,Ruchaud,Baratte,Bach
, p. 1061 - 1069 (2019/09/06)
A series of propargyl and allyl carbamates were prepared directly from propargyl and allyl alcohols and phenyl or cyclohexyl isocyanate or indirectly by generating the isocyanates in situ from the corresponding Cbz-protected amines. The obtained carbamate
Mild and high-yielding molybdenum(VI) dichloride dioxide-catalyzed formation of Mono-, Di-, Tri-, and tetracarbamates from alcohols and aromatic or aliphatic isocyanates
Stock, Christian,Brueckner, Reinhard
, p. 2309 - 2330 (2012/11/07)
Both molybdenum(VI) dichloride dioxide (MoO2Cl2) and its dimethylformamide (DMF) complex catalyze the addition of alcohols to isocyanates giving carbamates. Most additions proceeded to completion at room temperature within 20 min using as little as 0.1 mol% of the catalyst when working on a 1-mmol scale or just 100 ppm working on a 20-mmol scale. Sterically encumbered substrates reacted to completion when 1 mol% of the catalyst was employed. Diols, triols, and tetraols reacted with monoisocyanates likewise, as did monofunctional alcohols and diisocyanates. These pairings furnished di-, tri-, tetra-, and dicarbamates, respectively. Reactants, which were poorly soluble in CH2Cl2 at room temperature required elevating the temperature and possibly choosing a higher-boiling solvent (ClCH 2CH2Cl, DMF) as well. Additions of diols to diisocyanates were feasible, too, giving polycarbamates as we presume. Copyright
Regioselective 1,3-dipolar cycloaddition reactions of 4-methylene-2- oxazolidinones with benzonitrile oxide
Newton, Rebecca,Savage, G. Paul
, p. 432 - 437 (2008/09/21)
Substituted 4-methylene-2-oxazolidinones were prepared in two steps by cyclizing O-propargyl carbamates, which in turn were prepared from propargyl alcohols and phenyl isocyanate. The 4-methylene-2-oxazolidinones underwent a 1,3-dipolar cycloaddition reac