5417-63-0 Usage
Description
3-Amino-2-naphthol is an organic compound with the molecular formula C10H9NO. It is a white crystalline solid that is soluble in water and has a characteristic amine-like odor. 3-AMINO-2-NAPHTHOL is known for its chemical reactivity and is often used as a building block in the synthesis of various organic compounds.
Uses
Used in Chemical Synthesis:
3-Amino-2-naphthol is used as a key intermediate in the synthesis of various organic compounds, including pharmaceuticals, dyes, and other specialty chemicals. Its unique chemical structure allows it to participate in a wide range of reactions, making it a versatile compound in the field of organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-Amino-2-naphthol is used as a starting material for the synthesis of various drugs. Some of the compounds synthesized using 3-Amino-2-naphthol include 2-naphthyl-3-NHSO2CF3, 1-naphthyl-5-NHSO2CF3, benzoquinolinequinone, and 3-chloro-2-napthol. These synthesized compounds have potential applications in the development of new medications for various diseases and conditions.
Used in Dye Industry:
3-Amino-2-naphthol is also used in the dye industry for the production of various types of dyes, particularly those with a naphthalene-based structure. These dyes are used in a wide range of applications, including textiles, plastics, and printing inks.
Used in Research and Development:
In addition to its practical applications, 3-Amino-2-naphthol is also used in research and development for the study of various chemical reactions and processes. Its unique properties make it an interesting compound for scientists to explore and understand, potentially leading to new discoveries and innovations in the field of chemistry.
Synthesis Reference(s)
Journal of the American Chemical Society, 72, p. 390, 1950 DOI: 10.1021/ja01157a105
Check Digit Verification of cas no
The CAS Registry Mumber 5417-63-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,1 and 7 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 5417-63:
(6*5)+(5*4)+(4*1)+(3*7)+(2*6)+(1*3)=90
90 % 10 = 0
So 5417-63-0 is a valid CAS Registry Number.
InChI:InChI=1S/C10H9NO/c11-9-5-7-3-1-2-4-8(7)6-10(9)12/h1-6,12H,11H2
5417-63-0Relevant articles and documents
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Wolf et al.
, p. 390 (1950)
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Antitumor agents. 5. Synthesis, structure - activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5H-benzopyridophenoxazin-5-ones, and 5H-benzopyridophenoxazin-5-ones with potent antiproliferative activity
Bolognese, Adele,Correale, Gaetano,Manfra, Michele,Lavecchia, Antonio,Novellino, Ettore,Pepe, Stefano
, p. 5110 - 5118 (2007/10/03)
New antiproliferative compounds, dimethyl-5H-pyrido[3,2-a]phenoxazin-5-ones (1-6), tetrahydro-5H-benzopyrido[2,3-j]phenoxazin-5-ones (7-9), and 5H-benzopyrido[3,2-a]phenoxazin-5-ones (10-12) were synthesized and evaluated against representative human neoplastic cell lines. Dimethyl derivatives 1-6 were more active against carcinoma than leukemia cell lines. The tetrahydrobenzo derivatives 7-9 were scarcely active, whereas the corresponding benzo derivatives 10-12 showed notable cytotoxicity against a majority of the tested cell lines. Molecular modeling studies indicated that the high potency of 10 and 11, the most cytotoxic compounds of the whole series, could be due to the position of the condensed benzene ring, which favors π-π stacking interactions with purine and pyrimidine bases in the DNA active site. Biological studies suggested that 10-12 have no effect on human topoisomerases I and II and that they induce arrest at the G2/M phase.
