5418-94-0

Basic information

• Product Name: 2-a)pyrimidin-4-one,2-chloro-4h-pyrido(
• Synonyms: 2-a)pyrimidin-4-one,2-chloro-4h-pyrido(;2-Chloro-4H-pyrido[1,2-a]pyrimidin-4-one;2-chloropyrido[1,2-a]pyrimidin-4-one
• CAS NO: 5418-94-0
• Molecular Formula: C₈H₅ClN₂O
• Molecular Weight: 180.594
• Mol File: 5418-94-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 287°Cat760mmHg
• Flash Point: 127.3°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 0.00256mmHg at 25°C
• Refractive Index: 1.662
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-a)pyrimidin-4-one,2-chloro-4h-pyrido((CAS DataBase Reference)
• NIST Chemistry Reference: 2-a)pyrimidin-4-one,2-chloro-4h-pyrido((5418-94-0)
• EPA Substance Registry System: 2-a)pyrimidin-4-one,2-chloro-4h-pyrido((5418-94-0)

Safety Data

• Hazardous Substances Data: 5418-94-0(Hazardous Substances Data)

Usage

Description

2-a)pyrimidin-4-one,2-chloro-4h-pyrido( is a chemical compound that belongs to the pyrimidinone class. It is characterized by the presence of a pyrimidine ring fused to a pyridine ring, with a chlorine atom at the 2nd position and a ketone group at the 4th position. 2-a)pyrimidin-4-one,2-chloro-4h-pyrido( is known for its potential applications in various fields due to its unique chemical structure and properties.

Uses

Used in Pharmaceutical Industry:
2-a)pyrimidin-4-one,2-chloro-4h-pyrido( is used as an intermediate in the synthesis of pyrimidin-5-one derivatives, which are important for the development of various pharmaceutical compounds. These derivatives have potential applications in the treatment of different diseases, including cancer, due to their ability to modulate various biological pathways.
Used in Chemical Research:
2-a)pyrimidin-4-one,2-chloro-4h-pyrido( is also used as a research compound in the field of organic chemistry. Its unique structure makes it an interesting subject for studying the properties and reactivity of pyrimidinone and pyridine-containing compounds. This can lead to the discovery of new synthetic methods and applications for this class of compounds.

InChI:InChI=1/C8H5ClN2O/c9-6-5-8(12)11-4-2-1-3-7(11)10-6/h1-5H

Upstream product

• 138305-21-2 ethyl 3-oxo-3-(pyridin-2-ylamino)propianoate 
• 504-29-0 2-aminopyridine 
• 123419-89-6 2-Methylthio-4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carboxylic acid 
• 84292-17-1 2-(dimethylamino)-4H-pyrido<1,2-a>pyrimidin-4-one 
• 27420-41-3 2-hydroxy-4H-pyrido<1,2-a>pyrimidin-4-one 
• 22288-66-0 2H,3H,4H-pyrido[1,2-a]pyrimidine-2,4-dione 
• 10025-87-3 trichlorophosphate 
• 237742-94-8 (2-pyridyl)iminopropadienone 
• 111680-69-4 2-chloro-N-phenyl-4H-pyrido<1,2-a>pyrimidin-4-imine 

Downstream Products

• 55395-30-7 2-hydrazinyl-4H-pyrido[1,2-a]pyrimidin-4-one 
• 16054-93-6 2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one 
• 1335239-80-9 2-(2'-acetylphenyl)-4H-pyrido[1,2-a]pyrimidin-4-one 
• 1335239-84-3 2-benzyl-4H-pyrido[1,2-a]pyrimidin-4-one 
• 1335239-79-6 2-[4-(trifluoromethyl)phenyl]-4H-pyrido[1,2-a]pyrimidin-4-one 
• 191218-37-8 2-(4'-methoxyphenyl)-4H-pyrido[1,2-a]pyrimidin-4-one 
• 867381-76-8 C₁₅H₁₀N₂O₃ 
• 1204420-27-8 3-(Hydroxymethyl)-2-phenoxy-4H-pyrido[1,2-a]pyrimidin-4-one 
• 685893-09-8 C₁₄H₁₀N₂O₂ 
• 1220910-27-9 4-imino-2-(methylthio)-5-oxo-1-phenyl-1,5-dihydro-4H-dipyrido-[1,2-a:2',3'-d]pyrimidine-3-carbonitrile 
• 33345-96-9 3-formyl-2-piperidino-4H-pyrido<1,2-a>pyrimidin-4-one 
• 111680-78-5 2-(phenylamino)-4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carbaldehyde 
• 154816-49-6 2-(4-methyl-1-piperazinyl)-4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carbaldehyde 
• 237742-94-8 (2-pyridyl)iminopropadienone 

Relevant articles and documents

QUINAZOLINONE COMPOUNDS AND DERIVATIVES THEREOF

Compounds of Formula I are useful inhibitors of tankyrase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

(2-Pyridyl)iminopropadienone

(2-Pyridyl)iminopropadienone 13 is generated by flash vacuum thermolysis (FVT) of 2-substituted pyrido[1,2-a]pyrimidin-4-ones 9 and observed by IR spectroscopy. Addition of HCl to 13 causes reversion to the starting material 9b, whereas addition of nucleophiles leads to malonic acid imide derivatives (23, 24, 26, 27, 28). The latter undergo thermal elimination of amines to regenerate 2-substituted pyridopyrimidinones. A competing retro-ene reaction occurs on FVT of 2-(dialkylamino)pyridopyrimidinones 9c,d, presumably in the oxoketenimine intermediates 22/25, with formation of the unsubstituted pyridopyrimidinone 31.