54201-67-1

Basic information

• Product Name: 7-p-Toluenesulfonylhydrazide Cholesterol 3-Acetate
• Synonyms: 7-p-Toluenesulfonylhydrazide Cholesterol 3-Acetate;4-Methyl-benzenesulfonic Acid 2-[(3β)-3-(Acetyloxy)cholest-5-en-7-ylidene]hydrazide;p-Toluenesulfonic Acid (3β-Hydroxycholest-5-en-7-ylidene)hydrazide Acetate
• CAS NO: 54201-67-1
• Molecular Formula: C₃₆H₅₄N₂O₄S
• Molecular Weight: 610.88996
• Product Categories: Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 54201-67-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: 7-p-Toluenesulfonylhydrazide Cholesterol 3-Acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 7-p-Toluenesulfonylhydrazide Cholesterol 3-Acetate(54201-67-1)
• EPA Substance Registry System: 7-p-Toluenesulfonylhydrazide Cholesterol 3-Acetate(54201-67-1)

Safety Data

• Hazardous Substances Data: 54201-67-1(Hazardous Substances Data)

Usage

Description

7-p-Toluenesulfonylhydrazide Cholesterol 3-Acetate is a cholesterol derivative characterized by its light yellow solid appearance. It is a compound that has been modified to possess specific functional groups, making it suitable for various applications in different industries.

Uses

Used in Pharmaceutical Industry:
7-p-Toluenesulfonylhydrazide Cholesterol 3-Acetate is used as an intermediate in the synthesis of 5,7-diene steroids for the pharmaceutical industry. These steroids are essential in the development of various medications, particularly those targeting hormonal imbalances and related conditions.
Used in Chemical Research:
As a cholesterol derivative, 7-p-Toluenesulfonylhydrazide Cholesterol 3-Acetate is also utilized in chemical research for the investigation of steroidal structures and their potential applications in drug development. Its unique properties allow researchers to explore new avenues in the synthesis and modification of steroidal compounds.

Upstream product

• 83-48-7 Stigmasterol 
• 4651-48-3 stigmasterol acetate 
• 10211-88-8 (20S)-3β-acetoxybisnorchol-5-en-22-al 
• 604-35-3 Cholesteryl acetate 
• 57-88-5 cholesterol 
• 809-51-8 7-ketocholesteryl acetate 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 1059-86-5 7-Dehydrocholesteryl acetate 
• 434-16-2 7-dehydrocholesterol 
• 67-97-0 vitamin D₃ 

Relevant articles and documents

Preparation method of 7-p-toluenesulfonylhydrazone-3-cholesterol ester

The invention discloses a preparation method of 7-p-toluenesulfonylhydrazone-3-cholesteryl ester, which comprises the following steps: carrying out hydrazone reaction on p-toluenesulfonylhydrazine and7ketone 3cholesteryl ester in a solvent under the catal

Cooperative Noncovalent Interactions Lead to a Highly Diastereoselective Sulfonyl-Directed Fluorination of Steroidal α,β-Unsaturated Hydrazones

A series of steroidal α,β-unsaturated hydrazones is presented whose behavior and reactivity are governed by various types of weak C-H hydrogen bonds. Several interesting features in a representative X-ray crystal structure and 1H NMR spectrum are examined that provide evidence for a unique bifurcated intramolecular C-H interaction. Moreover, these steroid derivatives undergo functionalization in the form of a highly regio- and stereoselective fluorination; the sulfonyl oxygen atoms are proposed to direct the fluorinating reagent through C-H hydrogen bonds.

New industrial method for producing vitamin D3 by taking wool fat as raw material

The invention provides a new industrial method for producing vitamin D3 by taking wool fat as a raw material. The new industrial method comprises the following steps: carrying out saponification and primary purification on the wool fat in a low alcohol solution, thus obtaining a cholesterol crude product; directly carrying out acetylation on the cholesterol crude product, thus obtaining high-purity cholesterol acetate; then sequentially carrying out oxidizing, hydrazone forming, hydrazone removing, hydrolyzing, illuminating and the like, thus obtaining the vitamin D3. A production technology disclosed by the invention is efficient, green and environment-friendly, is high in product yield and is suitable for industrial production, and the manufacturing cost of the vitamin D3 is greatly reduced; a saponification technology is ingenious in filtrate treatment, has no generation of waste liquid and waste and is more beneficial for environment protection.