5423-95-0

Basic information

• Product Name: 4-hydroxy-3-methylisoquinolin-1(2H)-one
• CAS NO: 5423-95-0
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.184
• Mol File: 5423-95-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 428.5°C at 760 mmHg
• Flash Point: 213°C
• Density: 1.297g/cm³
• Vapor Pressure: 4.17E-08mmHg at 25°C
• Refractive Index: 1.625
• CAS DataBase Reference: 4-hydroxy-3-methylisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-3-methylisoquinolin-1(2H)-one(5423-95-0)
• EPA Substance Registry System: 4-hydroxy-3-methylisoquinolin-1(2H)-one(5423-95-0)

Safety Data

• Hazardous Substances Data: 5423-95-0(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 14380-86-0 ethyl 2-(1,3-dioxoisoindolin-2-yl)propanoate 
• 124-41-4 sodium methylate 

Downstream Products

• 7114-80-9 3-methylisoquinolone 
• 861136-85-8 1-[3-(1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-ylamino)-phenyl]-ethanone 
• 861136-90-5 [3-(1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-ylamino)-phenyl]-methanol 
• 861136-87-0 (3-methansulfonyl-phenyl)-(1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-yl)-amine 
• 861136-88-1 N-[3-(1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-ylamino)-phenyl]-acetamide 
• 861136-86-9 3-(1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-ylamino)-N,N-dimethyl-benzamide 
• 861136-89-2 (1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-yl)-(3-trifluoromethoxy-phenyl)-amine 
• 7115-16-4 1-chloro-3-methyl-isoquinoline 
• 1125-80-0 3-methylisoquinoline 

Relevant articles and documents

Poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors based on a tetrahydro-1(2H)-isoquinolinone Scaffold: Synthesis, biological evaluation and X-ray crystal structure

The synthesis, activity and physical properties of two series of novel potent tetrahydro-1(2H)-isoquinolinone based PARP-1 inhibitors are described. The new structural classes with a non-planar ring system interact specifically with the PARP-1 protein at the nicotinamide-binding site. Georg Thieme Verlag Stuttgart.

On the Chemistry of Pyrrole Pigments, XCI: Copper Complexes of Pyridinologous Linear Tri- and Tetra-pyrroles as Cyclopropanation Catalysts

In addition to two recently described pyridinologous linear tri- and tetrapyrroles a biisoquinologous system was prepared and its geometrical features derived by means of NMR measurements and force field calculations.The copper complexes of these three ligands were isolated and characterized, and then used as catalysts in the cyclopropanation of styrene.The results were found to be similar to those reported for a variety of catalysts in literature.Thus, it was demonstrated that these systems can be used in principle as catalysts. - Keywords.Pyridinologous linear tri- and tetrapyrroles; Copper chelates; 1H-NMR spectra; Configuration; Conformation; Cyclopropanation catalyst.