54231-45-7

Basic information

• Product Name: 4-(2-bromopyridin-3-yl)morpholine
• Synonyms: 4-(2-bromopyridin-3-yl)morpholine
• CAS NO: 54231-45-7
• Molecular Formula: C9H11BrN2O
• Molecular Weight: 243.10044
• Mol File: 54231-45-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(2-bromopyridin-3-yl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-bromopyridin-3-yl)morpholine(54231-45-7)
• EPA Substance Registry System: 4-(2-bromopyridin-3-yl)morpholine(54231-45-7)

Safety Data

• Hazardous Substances Data: 54231-45-7(Hazardous Substances Data)

Usage

General Description

4-(2-bromopyridin-3-yl)morpholine is a chemical compound that belongs to the class of morpholine derivatives. It consists of a morpholine ring with a 2-bromopyridin-3-yl group attached at the 4-position. 4-(2-bromopyridin-3-yl)morpholine has the molecular formula C10H11BrN2O, and it is used as a building block or intermediate in the synthesis of various pharmaceutical and agrochemical products. It is also being researched for its potential biological and pharmacological activities, including its antifungal, antibacterial, and anticancer properties. Additionally, it may have applications as a reagent in organic synthesis and as a potential drug candidate for the treatment of certain diseases.

Upstream product

• 54231-37-7 4-(2-nitropyridin-3-yl)morpholine 
• 54231-32-2 3-chloro-2-nitropyridine 
• 54231-33-3 3-bromo-2-nitropyridine 
• 54231-34-4 3-iodo-2-nitropyridine 
• 110-91-8 morpholine 
• 265981-13-3 2-bromo-3-iodo pyridine 

Relevant articles and documents

Developing backbone-modified Mor-DalPhos ligand variants for use in palladium-catalyzed C-N and C-C cross-coupling

The present contribution describes the systematic structural diversification of the ?°2-P,N DalPhos ligand family in an effort to improve catalytic efficiency in the monoarylation of ammonia and acetone. The study is focused primarily on modifying the backbone phenylene linker, while retaining the same bite angle and steric bulk as the Mor-DalPhos ligand through the use of P(1-Ad)2 and morpholine donors. Eight new variants of Mor-DalPhos were prepared; two of these feature a pyridine linker (L1, L2), and five others feature either electron-donating (L3, L4) or electron-withdrawing (L5-L7) substituents on the phenylene linker. Additionally, thiomorpholino substitution (L8) was performed to investigate the effects of a possible tridentate coordination mode. Precatalyst complexes of the general formula LPd(cinnamyl)Cl were prepared and characterized in both solution and solid state. Solution studies demonstrated a significant degree of lability in the Pd-N bond, whereby dynamic behavior is seen to be dependent on the nature of the ligand backbone. The utility of these new ligands in the palladium-catalyzed monoarylation of ammonia or acetone was then surveyed. Notably, pyridine-derived ligand variants (L1, L2) were observed to out-perform parent Mor-DalPhos in the latter transformations.