54236-98-5 Usage
General Description
2,4-Diamino-5-methoxymethylpyrimidine is a chemical compound that belongs to the pyrimidine class of organic compounds. It is a derivative of pyrimidine with an amino group at the 2 and 4 positions, and a methoxymethyl group at the 5 position. 2,4-Diamino-5-methoxymethylpyrimidine is commonly used as an intermediate in the synthesis of pharmaceuticals, particularly antiviral drugs, and is also used in the manufacture of biologically active compounds, such as nucleosides and nucleotides. Additionally, it has potential applications in the development of new drugs and therapeutic agents, particularly in the field of antiviral and anticancer research.
Check Digit Verification of cas no
The CAS Registry Mumber 54236-98-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,2,3 and 6 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 54236-98:
(7*5)+(6*4)+(5*2)+(4*3)+(3*6)+(2*9)+(1*8)=125
125 % 10 = 5
So 54236-98-5 is a valid CAS Registry Number.
54236-98-5Relevant articles and documents
Syntheses of Antibacterial 2,4-Diamino-5-benzylpyrimidines. Ormetoprim and Trimethoprim
Manchand, Percy S.,Rosen, Perry,Belica, Peter S.,Oliva, Gloria V.,Perrotta, Agostino V.,Wong, Harry S.
, p. 3531 - 3535 (2007/10/02)
A general and mild method for the synthesis of 2,4-diamino-5-benzylpyrimidines was achieved by the Friedel-Crafts reaction between 2-(methoxymethylene)-3-methoxypropanenitrile (10) and an activated aromatic substrate followed by treatment with guanidine.The method is illustrated by a synthesis of ormetoprim (2) in 75percent overall yield from 3,4-dimethoxytoluene (12).Efficient syntheses of trimethoprim (1) and 2 were also accomplished via prior base-catalyzed 1,3-prototropic isomerization of cinnamonitriles 19 and 20, respectively, followed by condensation with guanidine. 12 was prepared from 3-bromo-4-methoxytoluene by a Cu(I)-catalyzed displacement of bromine by methoxide and 4,5-dimethoxy-2-methylbenzaldehyde was obtained from 12 in 87percent yield by a pyridine-catalyzed Vilsmeier reaction using DMF-POCl3.
