54251-80-8 Usage
Description
1-Cyclopropylcyclopropan-1-ol is an organic compound characterized by its unique cyclopropane ring structure. It is a versatile building block in organic synthesis, particularly in the preparation of various complex molecules and pharmaceuticals.
Uses
Used in Pharmaceutical Industry:
1-Cyclopropylcyclopropan-1-ol is used as a reactant for the synthesis of arylpyridines, which are important structural motifs found in a wide range of biologically active compounds, including pharmaceuticals. Its application in this industry is due to its ability to facilitate the formation of these complex molecules through Mn(III)-mediated reactions with vinyl azides.
Used in Chemical Synthesis:
1-Cyclopropylcyclopropan-1-ol is also used as a reactant in the preparation of azabicyclo[3.3.1]nonenols and their derivatives. These compounds are valuable intermediates in the synthesis of various organic molecules and have potential applications in the development of new materials and pharmaceuticals. The use of 1-cyclopropylcyclopropan-1-ol in this context is attributed to its reactivity and the ease with which it can be transformed into a variety of different products through Mn(III)-mediated reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 54251-80-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,2,5 and 1 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 54251-80:
(7*5)+(6*4)+(5*2)+(4*5)+(3*1)+(2*8)+(1*0)=108
108 % 10 = 8
So 54251-80-8 is a valid CAS Registry Number.
54251-80-8Relevant articles and documents
PROCESS OF MAKING CFTR MODULATORS
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Paragraph 0418-0420; 0756; 0757, (2021/02/19)
The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.
Iron-Catalyzed Triazole-Enabled C-H Activation with Bicyclopropylidenes
Mo, Jiayu,Messinis, Antonis M.,Oliveira, Joa? C. A.,Demeshko, Serhiy,Meyer, Franc,Ackermann, Lutz
, p. 1053 - 1064 (2021/01/26)
C-H/C-C functionalizations with oxymethylated bicyclopropylidenes were accomplished with an iron catalyst under external oxidant-free conditions. The combination of the unique reactivity of bicyclopropylidenes with a robust iron(II) catalyst enabled C-C c
Copper-mediated tandem ring-opening/cyclization reactions of cyclopropanols with aryldiazonium salts: Synthesis of: N -arylpyrazoles
Liu, Jidan,Xu, Erjie,Jiang, Jinyuan,Huang, Zeng,Zheng, Liyao,Liu, Zhao-Qing
supporting information, p. 2202 - 2205 (2020/02/26)
A general method for the synthesis of structurally diverse N-arylpyrazoles from readily available cyclopropanols and aryldiazonium salts is disclosed. The reaction was conducted at room temperature within minutes with a broad substrate scope and excellent regioselectivity.
