54256-43-8

Basic information

• Product Name: 4-N-DECYLBENZOYL CHLORIDE
• Synonyms: P-DECYLBENZOYL CHLORIDE;4-N-DECYLBENZOYL CHLORIDE;4-DECYLBENZOYL CHLORIDE;4-decyl-benzoylchlorid;4-Decylbenzoic acid chloride;4-Decylbenzoyl chloride,98%
• CAS NO: 54256-43-8
• Molecular Formula: C₁₇H₂₅ClO
• Molecular Weight: 280.83
• EINECS: 259-046-7
• Mol File: 54256-43-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 172 °C (2 mmHg)
• Flash Point: 171-173°C/2mm
• Appearance: /
• Density: 1.0114 (estimate)
• Vapor Pressure: 1.29E-05mmHg at 25°C
• Refractive Index: 1.512-1.514
• Water Solubility: Reacts with water.
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 4-N-DECYLBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-N-DECYLBENZOYL CHLORIDE(54256-43-8)
• EPA Substance Registry System: 4-N-DECYLBENZOYL CHLORIDE(54256-43-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 24/25
• RIDADR: 3265
• TSCA: Yes
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 54256-43-8(Hazardous Substances Data)

Usage

Description

4-N-DECYLBENZOYL CHLORIDE, also known as 4-N-DECANOYLBENZOYL CHLORIDE, is an organic compound that serves as a crucial intermediate in the pharmaceutical and chemical industries. It is characterized by its clear light yellow liquid appearance and possesses unique chemical properties that make it valuable for various applications.

Uses

Used in Pharmaceutical Industry:
4-N-DECYLBENZOYL CHLORIDE is used as a pharmaceutical intermediate for the synthesis of various drugs and medications. Its chemical structure allows it to be a key component in the development of new pharmaceutical compounds, contributing to the advancement of medical treatments.
Used in Chemical Industry:
In the chemical industry, 4-N-DECYLBENZOYL CHLORIDE is utilized as a chemical intermediate for the production of different chemical products. Its unique properties enable it to be a vital building block in the synthesis of various chemicals, further expanding its applications and importance in the industry.
Overall, 4-N-DECYLBENZOYL CHLORIDE is a versatile compound with significant applications in both the pharmaceutical and chemical industries, playing a crucial role in the development and production of various products and medications.

InChI:InChI=1/C17H25ClO/c1-2-3-4-5-6-7-8-9-10-15-11-13-16(14-12-15)17(18)19/h11-14H,2-10H2,1H3

Upstream product

• 17049-50-2 n-decyl magnesium bromide 
• 106418-67-1 1-bromo-4-n-decyl benzene 
• 106-37-6 1.4-dibromobenzene 
• 38300-04-8 4-decylbenzoic acid 
• 79-37-8 oxalyl dichloride 
• 104-72-3 decylbenzene 

Downstream Products

• 70972-99-5 4-(n-decyl)benzaldehyde 
• 61518-87-4 4-Decyl-thiobenzoic acid S-(4-pentyl-phenyl) ester 
• 1037586-15-4 C₃₃H₅₀O₈S 
• 7408-29-9 4-decylphenylmethanol 
• 1353054-52-0 (S)-2-amino-3-(2-(4-(4-decylbenzoyl)phenyl)acetamido)-N-hexadecylpropanamide 
• 1353054-51-9 (S)-tert-butyl 3-(2-(4-(4-decylbenzoyl)phenyl)acetamido)-1-(hexadecylamino)-1-oxo-propan-2-ylcarbamate 
• 1353054-50-8 (S)-2-(tert-butoxycarbonylamino)-3-(2-(4-(4-decylbenzoyl)phenyl)acetamido)propanoic acid 
• 1353054-41-7 2-(4-((4-decylphenyl)(hydroxy)methyl)phenyl)ethanol 
• 1353054-46-2 (4-decylphenyl)(4-(2-(triisopropylsilyloxy)ethyl)phenyl)methanol 
• 1353054-45-1 C₃₀H₄₄O₃ 
• 82532-71-6 methyl p-n-decylbenzoate 
• 1210045-20-7 N-(1-cyanocyclopropyl)-4-decylbenzamide 
• 1050201-25-6 C₃₂H₃₉N₅O 
• 143698-21-9 1,5-[(4-Decylbenzoyl)imino]-1,5-dideoxy-D-glucitol, tetraacetate 

Relevant articles and documents

Nonpeptidic, Polo-Box Domain-Targeted Inhibitors of PLK1 Block Kinase Activity, Induce Its Degradation and Target-Resistant Cells

PLK1, polo-like kinase 1, is a central player regulating mitosis. Inhibition of the subcellular localization and kinase activity of PLK1 through the PBD, polo-box domain, is a viable alternative to ATP-competitive inhibitors, for which the development of resistance and inhibition of related PLK family members are concerns. We describe novel nonpeptidic PBD-binding inhibitors, termed abbapolins, identified through successful application of the REPLACE strategy and demonstrate their potent antiproliferative activity in prostate tumors and other cell lines. Furthermore, abbapolins show PLK1-specific binding and inhibitory activity, as measured by a cellular thermal shift assay and an ability to block phosphorylation of TCTP, a validated target of PLK1-mediated kinase activity. Additional evidence for engagement of PLK1 was obtained through the unique observation that abbapolins induce PLK1 degradation in a manner that closely matches antiproliferative activity. Moreover, abbapolins demonstrate antiproliferative activity in cells that are dramatically resistant to ATP-competitive PLK1 inhibitors.

Preparation of new substituted bis(benzoyl) peroxides under aqueous conditions in the presence of stearyltrimethylammonium chloride

A series of new substituted bis(benzoyl) peroxides has been synthesised from their corresponding acid chlorides in high yield. The reactions were carried out in aqueous sodium peroxide solution and butanone in the presence of 0.5% stearyltrimethylammonium chloride (STAC) at a temperature below 15°C. STAC improved the purity, and the fast addition improved the yield of the peroxides. Mass spectral analysis of substituted bis(benzoyl) peroxides using EI has been carried out for accurate mass determinations. Springer-Verlag 2003.

Mesomorphic Properties of Some 4,4'-Alkyl and Alkoxy Disubstituted Phenylbenzoates

A variety of new 4,4'-disubstituted phenylbenzoates with one and/or both substituents as alkyl (R) or alkoxy (RO) were prepared and their mesomorphic (liquid crystalline) properties determined for later use as standards for comparison with mesomorphic properties in other new 4,4'-disubstituted phenylbenzoates.Other esters of this type which had been previously reported, were prepared for physical studies of their mesophases and found to have different mesomorphic properties than those reported earlier.Still others were prepared to identify phases which were not determined previously.This paper presents new mesomorphic properties along with a comparison of the NMR spectra for the four possible analogs of these esters (R-R, R-OR), RO-R, RO-OR).Keywords: phenylbenzoates, mesogens, liquid crystals, NMR