5442-90-0

Basic information

• Product Name: 2-[2-(morpholin-4-yl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
• Synonyms: 1H-Isoindole-1,3(2H)-dione, 2-[2-(4-morpholinyl)-2-oxoethyl]-; 2-(2-morpholino-2-oxoethyl)-1H-isoindole-1,3(2H)-dione; 2-[2-(Morpholin-4-yl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
• CAS NO: 5442-90-0
• Molecular Formula: C₁₄H₁₄N₂O₄
• Molecular Weight: 274.272
• Mol File: 5442-90-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 488.3°C at 760 mmHg
• Flash Point: 249.1°C
• Density: 1.382g/cm³
• Vapor Pressure: 1.1E-09mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: 2-[2-(morpholin-4-yl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(morpholin-4-yl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione(5442-90-0)
• EPA Substance Registry System: 2-[2-(morpholin-4-yl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione(5442-90-0)

Safety Data

• Hazardous Substances Data: 5442-90-0(Hazardous Substances Data)

Usage

Chemical compound

2-[2-(morpholin-4-yl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione

Contains a morpholine ring

Heterocyclic organic compound used in pharmaceutical and chemical production

Contains an isoindole-1,3-dione ring

Important building block in organic synthesis

Potential applications in pharmaceutical industry

Possible precursor for drug synthesis

Complex structure

Requires extensive study and research to understand properties and potential uses

Upstream product

• 4702-13-0 N-phthaloylglycine 
• 110-91-8 morpholine 
• 39538-08-4 Phthalimidoacetic acid imidazolide 
• 85-44-9 phthalic anhydride 
• 1440-61-5 N-chloroacetylmorpholine 
• 1074-82-4 potassium phtalimide 
• 6780-38-7 N-phthaloylglycine chloride 

Downstream Products

• 51769-87-0 N-benzoylaminoacetic acid morpholide 
• 56414-96-1 2-amino-1-morpholinoethanone 

Relevant articles and documents

Synthesis and anticonvulsant properties of new acetamide derivatives of phthalimide, and its saturated cyclohexane and norbornene analogs

The synthesis and anticonvulsant properties of new piperazine or morpholine acetamides derived from 2-(1,3-dioxoisoindolin-2-yl)-, 2-(1,3-dioxo-3a,4,5,6,7, 7a-hexahydroisoindol-2-yl-) and (3,5-dioxo-4-azatricyclo[5.2.1.0 2,6]dec-8-en-4-yl)-acetic acid were described. Initial anticonvulsant screening was performed using maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) seizures tests. The neurotoxicity was determined applying the minimal motor impairment rotarod test. The in vivo results revealed that numerous compounds were effective in the MES screen. The most active was 2-{2-[4-(4-fluorophenyl)piperazin-1-yl]-2-oxoethyl}isoindoline-1,3-dione (12) that revealed protection in the electrically induced seizures at a dose of 30 mg/kg and 100 mg/kg 0.5 h and 4 h after i.p. administration in mice respectively. This molecule given orally in rats at a dose of 30 mg/kg was more potent than reference anticonvulsant - phenytoin.