54424-12-3

Basic information

• Product Name: 5-[(acetyl-methyl-amino)-methyl]-O^2',O^3',O^5'-tribenzoyl-5-methylaminomethyl-2-thio-uridine
• CAS NO: 54424-12-3
• Molecular Weight: 657.701
• Mol File: 54424-12-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-[(acetyl-methyl-amino)-methyl]-O^2',O^3',O^5'-tribenzoyl-5-methylaminomethyl-2-thio-uridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(acetyl-methyl-amino)-methyl]-O^2',O^3',O^5'-tribenzoyl-5-methylaminomethyl-2-thio-uridine(54424-12-3)
• EPA Substance Registry System: 5-[(acetyl-methyl-amino)-methyl]-O^2',O^3',O^5'-tribenzoyl-5-methylaminomethyl-2-thio-uridine(54424-12-3)

Safety Data

• Hazardous Substances Data: 54424-12-3(Hazardous Substances Data)

Upstream product

• 54424-08-7 5-(N-Methylacetamidomethyl)-2-thiouracil 
• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 54424-10-1 N-methyl-N-(4-trimethylsilanyloxy-2-trimethylsilanylsulfanyl-pyrimidin-5-ylmethyl)-acetamide 

Downstream Products

• 32860-54-1 2-thio-5-<(methylamino)methyl>uridine 

Relevant articles and documents

Nucleoside Syntheses, XXI. Synthesis of 5-Methylaminomethyl-2-thiouridine, a Rare Nucleoside from t-RNA

The synthesis of 5-methylaminomethyl-2-thiouridine (1), a rare nucleoside from t-RNA, starting from the appropriate 2-thiouracil and ribose derivatives is described.During the silyl Hilbert-Johnson nucleoside synthesis with silver perchlorate the tert-butoxycarbonyl (Boc) aminoprotecting group in the 2-thiouracil moiety is removed.This cleavage is due to the intermediate formation of trimethylsilyl perchlorate.Preparative applications of this new type of Lewis acids are mentioned.