54453-93-9

Basic information

• Product Name: ETHYL 2-CHLOROISONICOTINATE
• Synonyms: ETHYL 2-CHLOROISONICOTINATE;2-CHLORO-ISONICOTINIC ACID ETHYL ESTER;2-CHLOROPYRIDINE-4-CARBOXYLIC ACID ETHYL ESTER;2-CHLORO-4-PYRIDINECARBOXYLIC ACID ETHYL ESTER;Ethyl 2-chloro-4-pyridinecarboxylate;Ethyl 2-chloroisonicotinate ,98%;Tpc-py018;ethyl 2-chloroisonicotinate(SALTDATA: FREE)
• CAS NO: 54453-93-9
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Product Categories: Pyridine;Pyridines;pyridine series
• Mol File: 54453-93-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 269.2 °C at 760 mmHg
• Flash Point: 116.6 °C
• Appearance: /
• Density: 1.245 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: ETHYL 2-CHLOROISONICOTINATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-CHLOROISONICOTINATE(54453-93-9)
• EPA Substance Registry System: ETHYL 2-CHLOROISONICOTINATE(54453-93-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 54453-93-9(Hazardous Substances Data)

Usage

Chemical Properties

Yellow liquid

Upstream product

• 6313-54-8 2-chloroisonicotinic acid, 
• 79-37-8 oxalyl dichloride 
• 14906-37-7 ethyl isonicotinate N-oxide 
• 13602-12-5 Isonicotinic acid N-oxide 
• 64-17-5 ethanol 

Downstream Products

• 89465-51-0 2-hydrazinylpyridine-4-carbohydrazide 
• 1570-45-2 isonicotinic acid ethylester 
• 654663-42-0 2-(4-[(tert-butoxy)carbonyl]piperazin-1-yl)pyridine-4-carboxylic acid 
• 13362-30-6 2-amino-4-ethoxycarbonyl-pyridine 
• 58481-04-2 2-chloroisonicotinic acid hydrazide 
• 1357083-16-9 2-(benzylthio)-5-(2-chloropyridin-4-yl)-1,3,4-oxadiazole 
• 1221448-70-9 5-(4-ethoxycarbonylpyridine-2-yl)-2, 3-dihydroindole-1-carboxylic acid benzyl ester 
• 1239581-09-9 C₁₈H₁₉ClN₂O₂ 
• 1034132-14-3 ethyl 2-chloro-3-iodoisonicotinate 
• 290300-93-5 2-(4-methyl-piperazin-1-yl)-isonicotinic acid ethyl ester 
• 427886-50-8 Ethyl 2-(3,5-dimethoxy-4-isopropoxyphenyl)isonicotinate 
• 427886-22-4 ethyl 2-(4-chloro-3,5-dimethoxyphenyl)isonicotinate 
• 427886-03-1 2-(3,4,5-trimethoxyphenyl)isonicotinic Acid 
• 482376-05-6 ethyl 2-(3,4-dimethoxyphenyl)isonicotinate 

Relevant articles and documents

Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents

A series of novel 1,3,4-oxadiazole thioether derivatives (compounds 9-44) were designed and synthesized as potential inhibitors of thymidylate synthase (TS) and as anticancer agents. The in vitro anticancer activities of these compounds were evaluated against three cancer cell lines by the MTT method. Among all the designed compounds, compound 18 bearing a nitro substituent exhibited more potent in vitro anticancer activities with IC50 values of 0.7 ± 0.2, 30.0 ± 1.2, 18.3 ± 1.4 μM, respectively, which was superior to the positive control. In the further study, it was identified as the most potent inhibitor against two kinds of TS protein (for human TS and Escherichia coli TS, IC50 values: 0.62 and 0.47 μM, respectively) in the TS inhibition assay in vitro and the most potent antibacterial agents with MIC (minimum inhibitory concentrations) of 1.56-3.13 μg/mL against the tested four bacterial strains. Molecular docking and 3D-QSAR study supported that compound 18 can be selected as dual antitumor/antibacterial candidate in the future study.

INSECT BEHAVIOUR MODIFYING COMPOUNDS

The invention provides methods for controlling thrips populations using thrips-repelling and/or thrips-attracting agents. The agents are derivatives of pyridine. The invention also provides methods of preventing or minimising damage to plants by use of the same.

Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors

The present invention relates to a cyclic urea compound of formula I: as defined herein. The invention is also directed to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use, as an inhibitor on a protein kinase. Thus, it is useful for preventing or treating a physiological disorder capable of being modulated by inhibiting the activity of a protein kinase, such as a solid tumor.