5446-32-2 Usage
General Description
2-amino-4-(diethylsulfamoyl)butanoic acid is a chemical compound with the molecular formula C10H21N3O4S. It is a derivative of butanoic acid and contains both an amino group and a sulfamoyl group. 2-amino-4-(diethylsulfamoyl)butanoic acid is commonly used as a diuretic and can aid in the treatment of edema and other conditions related to fluid retention. It works by inhibiting the reabsorption of sodium and chloride ions in the kidneys, leading to increased urine production. Additionally, it is also utilized in the research and development of pharmaceuticals and other industrial applications.
Check Digit Verification of cas no
The CAS Registry Mumber 5446-32-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,4 and 6 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 5446-32:
(6*5)+(5*4)+(4*4)+(3*6)+(2*3)+(1*2)=92
92 % 10 = 2
So 5446-32-2 is a valid CAS Registry Number.
5446-32-2Relevant articles and documents
Investigation of mechanism of nitrogen transfer in glucosamine 6- phosphate synthase with the use of transition state analogs
Milewski, SlLawomir,Hoffmann, Maria,Andruszkiewicz, Ryszard,Borowski, Edward
, p. 283 - 296 (2007/10/03)
Several structural analogs of putative tetrahedral intermediates of the reaction catalyzed by the glutamine amide transfer domain of Candida albicans glucosamine 6-phosphate synthase have been designed and synthesized. Esters and amides of γ-phosphonic and γ-sulfonic analogs of glutamine and glutamic acid were tested as potential inhibitors of the enzyme. N-substituted amides 9 and 15 were found to be the strongest inhibitors in the series. Structure- activity relationship studies led to conclusions supporting the possibility of a direct nucleophilic attack of the glutamine amide nitrogen on an electrophilic site of the enzyme-bound fructose 6-phosphate as the most likely mechanism of nitrogen transfer in glucosamine 6-phosphate synthase.
