54468-55-2

Basic information

• Product Name: {(NH₂(CH₂)2NH(CH₂)2NH(CH₂)2NH₂)Cu(H₂O)2}⁽²⁺⁾
• Synonyms: {(NH₂(CH₂)2NH(CH₂)2NH(CH₂)2NH₂)Cu(H₂O)2}⁽²⁺⁾
• CAS NO: 54468-55-2
• Molecular Weight: 245.812
• Mol File: 54468-55-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: {(NH₂(CH₂)2NH(CH₂)2NH(CH₂)2NH₂)Cu(H₂O)2}⁽²⁺⁾(CAS DataBase Reference)
• NIST Chemistry Reference: {(NH₂(CH₂)2NH(CH₂)2NH(CH₂)2NH₂)Cu(H₂O)2}⁽²⁺⁾(54468-55-2)
• EPA Substance Registry System: {(NH₂(CH₂)2NH(CH₂)2NH(CH₂)2NH₂)Cu(H₂O)2}⁽²⁺⁾(54468-55-2)

Safety Data

• Hazardous Substances Data: 54468-55-2(Hazardous Substances Data)

Relevant articles and documents

Methyl group steric effects on the kinetics of the copper(II)-tripeptide reactions with triethylenetetramine

Rates of reaction of triethylenetetramine (trien) with doubly deprotonated (tripeptido)cuprate(II) complexes are measured as a function of the number and position of methyl groups in the amino acid residues. Twelve tripeptides that consist of glycyl (G), L-alanyl (A), and α-aminoisobutyryl (Aib) residues are compared. The Cu(H-2Aib3)- complex reacts 8 orders of magnitude more slowly with trien than does the Cu(H-2G3)- complex. Methyl groups on the α-carbon of the second and third amino acid residues (from the amino terminus) decrease the rate of the trien substitution reaction to a much greater extent than methyl groups on the first residue. An empirical correlation between the second-order rate constant (Ktrien, M-1 s-1 at 25.0°C, pH ? 11) and the number and position of the methyl groups is found: log ktrien = 6.7 - 0.2C1 - 2.2C2 - 1.6C3, where Ci denotes the number of methyl groups in the ith amino acid residue. The enormous changes in reactivity are attributed primarily to steric effects in these ligand-ligand exchange reactions.