544694-15-7Relevant articles and documents
Synthesis and biological evaluation of novel indoloazepine derivatives as non-peptide vasopressin V2 receptor antagonists
Matthews, Jay M.,Greco, Michael N.,Hecker, Leonard R.,Hoekstra, William J.,Andrade-Gordon, Patricia,De Garavilla, Lawrence,Demarest, Keith T.,Ericson, Eric,Gunnet, Joseph W.,Hageman, William,Look, Richard,Moore, John B.,Maryanoff, Bruce E.
, p. 753 - 756 (2007/10/03)
A series of novel 3,4,5,6-tetrahydro-1H-azepino[4,3,2-cd]indoles was synthesized and tested for vasopressin receptor antagonist activity. We identified compounds with high affinity for the human V2 receptor and good selectivity over the human V1a receptor