5447-86-9Relevant articles and documents
Preparation method of 10,10-dimethylanthrone
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, (2019/06/30)
The invention belongs to the field of drug synthesis and provides a novel method of synthesizing melitracen hydrochloride intermediate 10,10-dimethylanthrone. The 10,10-dimethylanthrone is prepared from phthalic anhydride as a start material through two-step Grignard reaction and three-step closed-ring reaction. The total yield is up to 30%, and the purity of the finished intermediate is higher than 98.0%. Compared with traditional synthetic processes, the novel process herein has simple steps and greatly reduced production cost, causes little environmental pollution and helps greatly solve the environmental issue caused by the production of 10,10-dimethylanthrone.
Regioselective alkylation of anthrone, 5,5-dimethyl-3-isoxazolidinone and 4-methylquinolone by phase transfer catalysis
Dehmlow, Eckehard Volker,Bollhoefer, Joerg,Thye, Gorden
, p. 113 - 115 (2007/10/03)
Anthrone (1) can be alkylated selectively to give O-, C,O- or C,C-substituted compounds 2, 4, or 5, respectively. Similarly, 5,5-dimethyl-3-isoxazolidinone (6) and 4-methylquinolone (9) yield N- or O-derivatives 7 and 8 or 10 and 11, respectively. The product ratios can be influenced strongly sometimes by use of different phase transfer catalysts, but the sensitivity of each reaction towards the catalysts is unique.
Free energy and entropy changes in vertical and nonvertical triplet energy transfer processes between rigid and nonrigid molecules. A laser photolysis study
Zhang, Daisy,Closs, Gerhard L.,Chung, Dutch D.,Norris, James R.
, p. 3670 - 3673 (2007/10/02)
The free energy and entropy changes associated with intermolecular triplet energy transfer (TT) processes were determined by direct measurement of the equilibrium constant using a laser flash photolysis technique. 10,10-Dimethylanthrone and 9,9-dimethylfluorene were synthesized and used as a "rigid" donor and acceptor, respectively, in comparison with 4-methylbenzophenone, a "nonrigid" donor, and 4-methylbiphenyl, a "nonrigid" acceptor, in the TT reactions. Both the nonrigid donor and the nonrigid acceptor lose entropy while going from the twisted ground state to the planar triplet state. The ΔS values for 4-methylbenzophenone and 4-methylbiphenyl are 0.5-1.0 and 2.5-3.0 gibbs/mol, respectively.