5448-00-0

Basic information

• Product Name: 2-nitrohexan-3-ol
• CAS NO: 5448-00-0
• Molecular Formula: C₆H₁₃NO₃
• Molecular Weight: 147.1723
• Mol File: 5448-00-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 233.5°C at 760 mmHg
• Flash Point: 100.1°C
• Density: 1.061g/cm³
• Vapor Pressure: 0.0103mmHg at 25°C
• Refractive Index: 1.45
• CAS DataBase Reference: 2-nitrohexan-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitrohexan-3-ol(5448-00-0)
• EPA Substance Registry System: 2-nitrohexan-3-ol(5448-00-0)

Safety Data

• Hazardous Substances Data: 5448-00-0(Hazardous Substances Data)

Upstream product

• 79-24-3 Nitroethane 
• 123-72-8 butyraldehyde 

Downstream Products

• 13325-11-6 2-amino-hexan-3-ol 
• 6065-17-4 2-nitrohex-2-ene 
• 14255-57-3 3-acetoxy-2-nitro-hexane 

Relevant articles and documents

Synthesis, Characterization and Catalytic Activity of Magnetic KI@Fe3O4 Nanoparticles for Henry Reaction Under Solvent Free Conditions

Abstract: In this paper, we, for the first time reported the synthesis of KI loaded Fe3O4 nanoparticles (KI@Fe3O4 NPs) and investigated its applications in the synthesis of β-nitroalcohol via Henry reaction at room temperature under solvent-free conditions. The synthesized KI@Fe3O4 nanoparticle was characterized by SEM, HRTEM, XRD, XPS, EDX, VSM and FT-IR spectroscopy techniques. The XRD peaks at 2θ = 21.9, 25.65, 33.54, 36.35, 40.97, 42.81, 44.79, 54.43, 57.37, 58.83 and 63.13° corresponds to the formation of crystalline KI@Fe3O4 NPs. The activity of the catalyst by varying the amount of KI loading on Fe3O4 NPs was also investigated. Mild reaction conditions, good yield, short reaction time, solvent-free conditions, easy recoverability and recyclability of the nanocatalysts are the major advantages of our method. Graphical Abstract: [Figure not available: see fulltext.].

Solvent-Free Henry and Michael Reactions with Nitroalkanes Promoted by Potassium Carbonate as a Versatile Heterogeneous Catalyst

The use of a simple weak inorganic base such as potassium carbonate facilitated the formation of carbon-carbon bonds through both the Henry and the Michael reactions with nitrocompounds. The application of this catalyst under environmentally friendly solventless heterogeneous conditions gave satisfactory to good yields of β-nitroalcohols, involving aliphatic and aromatic starting materials, as well as high to excellent yields in the formation of Michael adducts using several different Michael acceptors and nitroalkanes.

Dolomite (CaMg(CO3)2) as a recyclable natural catalyst in Henry, Knoevenagel, and Michael reactions

Iranian dolomite (CaMg(CO3)2) which consists of double-layered carbonates with Ca2+ and Mg2+ ions was utilized as a heterogeneous base catalyst in the CC, CN, and CS bond forming reactions via the Henry, Knoevenagel, aza-Michael, and thia-Michael transformations under mild conditions in water. Iranian dolomite has been characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Brunauer Emmett Teller (BET) and XRF chemical analysis, while its basic strength was evaluated by following the Hammett indicators procedure. This water-insoluble natural catalyst demonstrated high activity and was reusable.