54483-54-4Relevant articles and documents
Stereoselective synthesis of α-L-bicarbocyclic nucleosides as potential antiviral drugs
Demaison, Christine,Hourioux, Christophe,Roingeard, Philippe,Agrofoglio, Luigi A.
, p. 9175 - 9178 (1998)
Synthesis of hitherto unknown carbocyclic α-L-isomeric bicyclo[3.1.0]hexyl nucleosides (8-11) is described. The key intermediate 7 was synthesized in seven steps from the known chiral compound 1 through a stereoselective cyclopropanation under Furukawa conditions. Compounds 8-11 were evaluated as anti-HBV agents in HepG2T14 cells.
Bromohydrin reactions of Grieco's bicyclic lactone
Tello-Aburto, Rodolfo,Rios, Maria Yolanda,Swenson, Dale C.,Olivo, Horacio F.
scheme or table, p. 6853 - 6855 (2009/04/07)
The bromohydrin reaction in Grieco's bicyclic lactone 1 was reinvestigated. Two regioisomeric bromohydrins were obtained (2 and 8), and their configurations were unambiguously determined by X-ray diffraction analyses.
Synthesis of enantiomerically pure carbocyclic α-L-isomeric homonucleosides
Girard,Demaison,Lee,Agrofoglio
, p. 8745 - 8752 (2007/10/03)
Synthesis of hitherto unknown carbocyclic α-L-isomeric homonucleosides (8a-b, 9a-b) is described. The key intermediate 6 was synthesized from the known compound 1 as a chiral starting material. Construction of the heterocyclic moiety around the amino group of 6 afforded carbocyclic α-L- isomeric 2',3'-dideoxyhomonucleosides 8a-b and their 2',3'-didehydro-2',3'- dideoxy derivatives 9a-b.
