5452-31-3Relevant articles and documents
Synthesis, characterization and antimicrobial evaluation of some novel chromenopyridine, pyranochromene and 3-hetarylcoumarin derivatives
Engy, E. Elbialy,Khaled, S. Mohamed
, (2020/07/21)
3-Acetylcoumarin was used as a precursor for the synthesis of novel fused heterocyclic compounds as chromeno[3 ,4-c]pyridine, chromeno[4,3-h]pyridine and pyrano[3,4-c]chromene derivatives in addition to the synthesis of 3-hetarylchromene derivatives. The chemical structures of newly synthesized compounds were avowed by means of spectral and analysis data. The novel synthesized compounds were estimated as antibacterial agents against Staphylococcus aureus and Escherichia co/i bacteria.
2-Hydroxy-2-methyl-2H-1-benzopyran-3-carboxamide Derivatives
O'Callaghan, Conor N.,McMurry, T. Brian H.
, p. 643 - 649 (2007/10/03)
The reaction of 2-hydroxybenzaldehydes with 3-oxobutanamide affords 2,4-dihydroxy-2-methyl-2H-3,4-dihydro-1-benzopyran-3-carboxamides and 2-hydroxy-2-methyl-2H-1-benzopyran-3-carboxamides, depending on the particular aldehyde and the experimental conditions used.
The Hantzsch Synthesis with Salicylaldehyde Revised. On the Formation of Bridged Tetrahydropyridine Derivatives
Svetlik, Jan,Turecek, Frantisek,Hanus, Vladimir
, p. 563 - 566 (2007/10/02)
The Hantzsch condensation of salicylaldehyde with ethyl acetoacetate and ammonia has been re-examined.The reaction leads primarily to a 1,4-dihydropyridine intermediate which, after isomerization, undergoes a ring closure to give a bridged 1,4,5,6-tetrahydropyridine product, or is oxidized to 4-methyl-2-(2-oxo-2H-1-benzopyran-3-yl)(1)benzopyranopyridin-5-one.Bridged tetrahydropyridines with the 8-oxa-10-azatricyclo2,7>trideca-2,4,6,11-tetraene skeleton were found in the Hantzsch-type condensation of salicylaldehyde with malononitrile, ammonium acetate, and acetone or butan-2-one.A mechanism for these reactions is discussed.