54534-92-8Relevant articles and documents
NRF2 REGULATORS
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Page/Page column 123, (2017/01/02)
Provided are aryl analogs,pharmaceutical compositions containing them and their use as NRF2 regulators.
Structure and property based design of factor Xa inhibitors: Biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs
Young, Robert J.,Borthwick, Alan D.,Brown, David,Burns-Kurtis, Cynthia L.,Campbell, Matthew,Chan, Chuen,Charbaut, Marie,Convery, Maire A.,Diallo, Hawa,Hortense, Eric,Irving, Wendy R.,Kelly, Henry A.,King, N. Paul,Kleanthous, Savvas,Mason, Andrew M.,Pateman, Anthony J.,Patikis, Angela N.,Pinto, Ivan L.,Pollard, Derek R.,Senger, Stefan,Shah, Gita P.,Toomey, John R.,Watson, Nigel S.,Weston, Helen E.,Zhou, Ping
, p. 28 - 33 (2008/09/17)
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating basic biaryl P4 groups, producing highly potent inhibitors with significant anticoagulant activities and encouraging oral pharmacokinetic profiles.