5455-67-4

Basic information

• Product Name: 2-hydroxy-N-methyl-N-phenylpropanamide
• CAS NO: 5455-67-4
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.2157
• Mol File: 5455-67-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 290.1°C at 760 mmHg
• Flash Point: 129.3°C
• Density: 1.152g/cm³
• Vapor Pressure: 0.000971mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: 2-hydroxy-N-methyl-N-phenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-N-methyl-N-phenylpropanamide(5455-67-4)
• EPA Substance Registry System: 2-hydroxy-N-methyl-N-phenylpropanamide(5455-67-4)

Safety Data

• Hazardous Substances Data: 5455-67-4(Hazardous Substances Data)

Upstream product

• 849585-22-4 LACTIC ACID 
• 100-61-8 N-methylaniline 
• 97-64-3 ethyl 2-hydroxypropionate 
• 547-64-8 methyl lactate 
• 617-57-2 2-(2-hydroxy-1-oxopropoxy)propionic acid 
• 251346-03-9 2-iodo-N-methyl-N-phenylpropanamide 
• 61110-50-7 N-methyl-N-phenyl-2-oxopropanamide 
• 95-96-5 D,L-lactide 
• 2620-11-3 2-bromo-N-methyl-N-phenylpropanamide 
• 5827-78-1 N-methyl-N-phenylpropanamide 

Relevant articles and documents

Copper-catalyzed synthesis of azaspirocyclohexadienones from ∝-azido- N -arylamides under an oxygen atmosphere

A copper-catalyzed reaction of ∝-azido-N-arylamides was found to proceed under an oxygen atmosphere to afford azaspirocyclohexadienones. The present transformation is carried out by a sequence of denitrogenative formation of iminyl copper species from ∝-azido-N-arylamides and their imino-cupration with an intramolecular benzene ring on the amido nitrogen followed by consecutive formation of C-O bonds. The preliminary investigation revealed that molecular oxygen is a prerequisite for achieving the present catalytic cyclization and that one of the oxygen atoms of O2 was found to be incorporated into the cyclohexadienone moiety.

Efficient radical oxygenation of α-lodocarboxylic acid derivatives

(equation presented) Treatment of α-iodocarboxylic acid derivatives with 2 equiv of triethylborane under oxygen atmosphere gives the corresponding α-hydroxy add derivatives This method is based on an iodine atom transfer from the ethyl radical, generated by the reaction of riethylborane and oxygen, with the α-iodocarbonyl compound. It offers several advantages over classical ionic substitution reactions: no elimanation product is observed tertiary iodides are efficiently converted to alcohos, and finally, this one-step procedure is working with substrates sensitive to nucleophiles.