5458-14-0

Basic information

• Product Name: 2-(TRIFLUOROACETAMIDO)ETHYLAMINE HYDROCHLORIDE
• Synonyms: 2-(TRIFLUOROACETAMIDO)ETHYLAMINE HYDROCHLORIDE;N-(2-aminoethyl)-2,2,2-trifluoroacetamide(SALTDATA: HCl);N-(2-aminoethyl)-2,2,2-trifluoroacetamide
• CAS NO: 5458-14-0
• Molecular Formula: C₄H₇F₃N₂O
• Molecular Weight: 192.57
• Mol File: 5458-14-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 211.7°Cat760mmHg
• Flash Point: 81.8°C
• Appearance: /
• Density: 1.294g/cm³
• Vapor Pressure: 0.18mmHg at 25°C
• Refractive Index: 1.384
• PKA: 11.18±0.10(Predicted)
• CAS DataBase Reference: 2-(TRIFLUOROACETAMIDO)ETHYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TRIFLUOROACETAMIDO)ETHYLAMINE HYDROCHLORIDE(5458-14-0)
• EPA Substance Registry System: 2-(TRIFLUOROACETAMIDO)ETHYLAMINE HYDROCHLORIDE(5458-14-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 5458-14-0(Hazardous Substances Data)

Usage

General Description

2-(Trifluoroacetamido)ethylamine hydrochloride is a chemical compound known for its unique properties and vital uses in various scientific applications. 2-(TRIFLUOROACETAMIDO)ETHYLAMINE HYDROCHLORIDE possesses the chemical formula C4H7ClF3N2O, indicating that it is composed of carbon, hydrogen, chlorine, fluorine, nitrogen, and oxygen. In its purest form, it appears as a solid substance, typically in a crystalline or powder state. Furthermore, it is commonly used as an intermediate in the synthesis of pharmaceuticals or for research and development purposes. Researchers must follow safety protocols while handling this chemical due to its potential for causing eye irritation or skin reactivity.

InChI:InChI=1/C4H7F3N2O/c5-4(6,7)3(10)9-2-1-8/h1-2,8H2,(H,9,10)

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 107-15-3 ethylenediamine 
• 160502-09-0 tert-butyl (2-(2,2,2-trifluoroacetamido)ethyl)carbamate 
• 333-18-6 1,2-diaminoethane dihydrochloride 

Downstream Products

• 496945-43-8 N-[2-[N-[3-[4-(N-tert-butoxycarbonylaminomethyl)phenyl]propyl]amino]ethyl]trifluoroacetamide 
• 53672-88-1 3-<<2-(trifluoroacetamido)ethyl>amino>-1-phenoxypropan-2-ol 

Relevant articles and documents

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The invention relates to a green synthesis method of sitagliptin intermediate, and belongs to the technical field of drug intermediate synthesis. In order to solve the problems that an existing pollution is large and unstable, a green synthesis method of sitagliptin intermediate is provided, and the method comprises the following steps: in an ether solvent, reacting trifluoroacetic acid ethyl ester with ethylenediamine to generate 2 - trifluoroacetamide ethyl ethylamine. Under the presence of an acid binding agent, 2 - trifluoroacetamide ethyl ethylamine and halogenated ethyl acetate are condensed and reacted under the conditions of 45 °C - 65 °C DEG C to form an intermediate, and then, the temperature is raised to 90 - 110 °C for cyclization reaction to generate N - trifluoroacetyl piperidine. The N -trifluoroacetyl piperidine ketone is reacted with hydrazine hydrate to generate 1 -trifluoroacetylamino -2 -piperazinone. The product is reacted with hydrochloric acid to form a ring-forming reaction, and a product sitagliptin intermediate is obtained. The method provided by the invention has the advantages of high product yield and purity on the whole, and has the advantage of environmental friendliness.

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