5459-95-0

Basic information

• Product Name: N,N-DIETHYL-N'-METHYL-1,3-PROPANEDIAMINE
• Synonyms: N,N-DIETHYL-N'-METHYL-1,3-PROPANEDIAMINE;AKOS BC-1117;N,N-diethyl-N'-methylpropane-1,3-diamine;N1,N1-Diethyl-N3-methyl-1,3-propanediamine;diethyl-[3-(methylamino)propyl]amine
• CAS NO: 5459-95-0
• Molecular Formula: C₈H₂₀N₂
• Molecular Weight: 144.26
• EINECS: 226-734-3
• Mol File: 5459-95-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N,N-DIETHYL-N'-METHYL-1,3-PROPANEDIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIETHYL-N'-METHYL-1,3-PROPANEDIAMINE(5459-95-0)
• EPA Substance Registry System: N,N-DIETHYL-N'-METHYL-1,3-PROPANEDIAMINE(5459-95-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 5459-95-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1297, 1946 DOI: 10.1021/ja01211a054

Upstream product

• 104-77-8 3-diethylaminopropyl chloride 
• 74-89-5 methylamine 
• 864248-25-9 (3-diethylamino-propyl)-carbamic acid methyl ester 
• 104-78-9 diethylaminopropylamine 
• 20824-58-2 2-(3-diethylaminopropyl)-1H-isoindole-1,3(2H)-dione 
• 99114-71-3 N-(3-diethylamino-propyl)-formamide 
• 4535-85-7 3-diethylaminopropylchloride hydrochloride 

Downstream Products

• 864244-82-6 1-(3-diethylaminopropyl)-3-[4-(2-fluoro-4-nitrophenoxy)pyridin-2-yl]-1-methylurea 
• 864245-88-5 3-[6-(2-Fluoro-4-nitrophenoxy)pyrimidin-4-yl]-1-(3-diethylaminopropyl)-1-methylurea 
• 864242-06-8 N-(4-{2-[3-(3-diethylaminopropyl)-3-methylureido]pyridin-4-yloxy}phenyl)-N'-(4-fluorophenyl)malonamide 
• 864244-83-7 1-(3-Diethylaminopropyl)-3-[4-(4-amino-2-fluorophenoxy)pyridin-2-yl]-1-methylurea 

Relevant articles and documents

NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (3)

A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor activity, angiogenesis inhibitory activity and cancer metastasis inhibitory activity. [R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents -CH=, nitrogen or the like.]

Long-range anisotropic effects of long chain amides

In 1H-NMR spectra of amids with long-chain aliphatic N-substituents one observes - despite of the free mobility of the aliphatic chain - splitting of the signals of the terminal methyl groups which is caused by the hindered rotation of the amide bond. - Keywords: Amides; Hindered rotation; 1H-NMR