5460-34-4

Basic information

• Product Name: 1-(8-chloro-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-1-deoxypentitol
• CAS NO: 5460-34-4
• Molecular Formula: C₁₆H₁₇ClN₄O₆
• Molecular Weight: 396.7824
• Mol File: 5460-34-4.mol
• Article Data: 2

Chemical Properties

• Density: 1.79g/cm³
• Refractive Index: 1.761
• CAS DataBase Reference: 1-(8-chloro-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-1-deoxypentitol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(8-chloro-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-1-deoxypentitol(5460-34-4)
• EPA Substance Registry System: 1-(8-chloro-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-1-deoxypentitol(5460-34-4)

Safety Data

• Hazardous Substances Data: 5460-34-4(Hazardous Substances Data)

Usage

Chemical class

Pteridines

Derivative of

Folic acid

Application

Antifolate drug

Medical uses

Treatment of certain types of cancer, rheumatoid arthritis, and psoriasis

Mechanism of action

Inhibits the enzyme dihydrofolate reductase

Enzyme involvement

Dihydrofolate reductase (DHFR)

Enzyme function

Synthesis of DNA and RNA

Effect on cells

Disrupts growth and multiplication of cancer cells and other rapidly dividing cells

Importance

Key drug in the treatment of several medical conditions

Combination therapy

Often used with other chemotherapy drugs

Upstream product

• 95-74-9 3-chloro-p-toluidine 
• 7149-79-3 N-(3-chloro-4-methylphenyl)acetamide 
• 7149-78-2 5-chloro-4-methyl-2-nitroacetanilide 
• 1207983-25-2 2-(5-chloro-4-methyl-2-nitrophenylamino)tetrahydropyran-3,4,5-triol 
• 7149-80-6 5-chloro-4-methyl-2-nitroaniline 
• 50-69-1 D-ribose 
• 61066-33-9 pyrimidine-2,4,5,6(1H,3H)-tetraone 
• 1207983-26-3 (2R,3S,4S)-5-(2-amino-5-chloro-4-methylphenylamino)pentane-1,2,3,4-tetraol 

Downstream Products

• 1207984-80-2 10-(2-(benzylamino)ethyl)-8-chloro-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione 
• 1207984-86-8 tert-butyl benzyl(2-(8-chloro-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethyl)carbamate 
• 1207984-88-0 tert-butyl benzyl(2-(8-(cyclopentyloxy)-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethyl)carbamate 
• 1207984-77-7 10-(2-(benzylamino)ethyl)-8-(cyclopropylamino)-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione 2,2,2-trifluoroacetate 
• 1207984-84-6 10-(2-(benzylamino)ethyl)-8-(cyclopentyloxy)-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione trifluoroacetate 

Relevant articles and documents

FLAVIN DERIVATIVES

The present invention relates novel flavin derivatives and other flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives. The invention also provides method of making novel flavin derivatives.