54610-70-7

Basic information

• Product Name: 2-AMIDINOTHIOPHENE HYDROCHLORIDE
• Synonyms: 2-THIOPHENECARBOXAMIDINE HCL;2-AMIDINOTHIOPHENE HYDROCHLORIDE;BUTTPARK 43\57-19;THIOPHENE-2-CARBOXIMIDAMIDE HYDROCHLORIDE;thiophene-2-carboximidamideHCl;Thiophene-2-Carboximidamide;Thiophene-2-carboximidamide hydrochloride, 95+%;2-AMIDINOTHIOPHENEYDROCHLORIDE, 95+%
• CAS NO: 54610-70-7
• Molecular Formula: C₅H₆N₂S*ClH
• Molecular Weight: 162.64
• Product Categories: pharmacetical;Thiophenes & Benzothiophenes;Thiophenes & Benzothiophenes
• Mol File: 54610-70-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 172-175°C
• Boiling Point: 220.8°C at 760 mmHg
• Flash Point: 87.3°C
• Appearance: /
• Vapor Pressure: 0.111mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-AMIDINOTHIOPHENE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMIDINOTHIOPHENE HYDROCHLORIDE(54610-70-7)
• EPA Substance Registry System: 2-AMIDINOTHIOPHENE HYDROCHLORIDE(54610-70-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 26-36/37/39-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 54610-70-7(Hazardous Substances Data)

Usage

General Description

2-AMIDINOTHIOPHENE HYDROCHLORIDE is a chemical compound that is commonly used in pharmaceutical and research applications. It is a hydrochloride salt of 2-amidinothiophene, which is a derivative of thiophene. This chemical has been found to exhibit antiviral and antiproteinase activity, making it a potential candidate for drug development. It is also used as a reagent in organic synthesis, particularly in the preparation of heterocyclic compounds. Additionally, it has been investigated for its potential use in treating respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Overall, 2-AMIDINOTHIOPHENE HYDROCHLORIDE is a versatile compound with various potential applications in the pharmaceutical and research fields.

InChI:InChI=1/C5H6N2S.ClH/c6-5(7)4-2-1-3-8-4;/h1-3H,(H3,6,7);1H

Upstream product

• 1003-31-2 thiophene-2-carbonitrile 
• 53370-51-7 N'-hydroxythiophene-2-carboximidamide 
• 54610-49-0 methyl thiophene-2-carbimidate hydrochloride 

Downstream Products

• 942265-20-5 5-(2-amino-5-chlorophenyl)-3-(2-thienyl)-1H-1,2,4-triazole 
• 848949-62-2 4-(2-Azido-ethyl)-5-(4-methoxy-phenyl)-2-thiophen-2-yl-1H-imidazole 
• 952579-98-5 5-diethoxymethyl-2-thiophen-2-ylpyrimidine 
• 301846-31-1 Ethyl 5-amino-4-(3-methoxyphenyl)-2-(2-thienyl)-thieno[2,3-d]pyrimidine-6-carboxylate 
• 1334238-52-6 4-(azulen-1-yl)-6-phenyl-2-(thiophen-2-yl)pyrimidine 
• 262614-07-3 N-(4-methoxyphenyl)thiophene-2-carboximidamide 
• 848949-46-2 C₂₅H₂₁N₃O₃S 
• 330844-64-9 1-(imino-thiophen-2-yl-methyl)-3-phenyl-thiourea 

Relevant articles and documents

Silver-catalyzed [3+2+1] annulation of aryl amidines with benzyl isocyanide

A silver-catalyzed [3+2+1] annulation of amidines with benzyl isocyanide toward 2,4-diaryl-1,3,5-triazines was developed. A variety of symmetrical and unsymmetrical products were obtained in moderate to good yields. This work also features an oxidant-free approach to 2,4-disubstituted triazines.

HETEROCYCLIC COMPOUND

The problem of the present invention is to provide a compound having a PDE2A inhibitory action, and useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

Synthesis and SAR of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents

The synthesis and SAR of a series of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents are described. This series of 2-heteroarylpyrimidines was developed by modifying a series of anti-tumor [1,2,4]triazolo[1,5-a]pyrimidines and 2-cyanoaminopyrimidines we reported earlier. For the 2-heteroaryl group, the best activity is obtained when the heteroaryl group has a nitrogen atom at the ortho-position to the pyrimidyl core. The structure-activity relationship for the rest of the molecule in this 2-heteroarylpyrimidine series mimics that of the [1,2,4]triazolo[1,5-a]pyrimidine series. Like triazolopyrimidines and 2-cyanoaminopyrimidines, the 2-heteroarylpyrimidines retain the capability to overcome multidrug resistance due to Pgp. Mechanism of action studies showed that the lead compounds behaved in the same manner as triazolopyrimidines and 2-cyanoaminopyrimidines. The lead compounds in this series are more potent than the corresponding triazolopyrimidines in vitro and in vivo. Compound 21 (PTI-868) showed tumor growth inhibition in several nude mouse xenograft models, and was selected to advance to preclinical development.