5463-16-1

Basic information

• Product Name: 2-Bromo-N-heptylacetamide
• Synonyms: 2-Bromo-N-heptylacetamide
• CAS NO: 5463-16-1
• Molecular Formula: C₉H₁₈BrNO
• Molecular Weight: 236.14932
• Mol File: 5463-16-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 326°Cat760mmHg
• Flash Point: 150.9°C
• Appearance: /
• Density: 1.203g/cm³
• Vapor Pressure: 0.000222mmHg at 25°C
• Refractive Index: 1.473
• CAS DataBase Reference: 2-Bromo-N-heptylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-N-heptylacetamide(5463-16-1)
• EPA Substance Registry System: 2-Bromo-N-heptylacetamide(5463-16-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5463-16-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H18BrNO/c1-2-3-4-5-6-7-11-9(12)8-10/h2-8H2,1H3,(H,11,12)

Upstream product

• 111-68-2 1-Heptylamine 
• 598-21-0 2-Bromoacetyl bromide 

Downstream Products

• 1025988-04-8 2-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-N-heptyl-acetamide 
• 1451412-18-2 2-{1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl}-N-heptylacetamide 
• 161669-65-4 2-<(4,5-diphenyl-1H-imidazol-2-yl)thio>-N-heptyl-1-ethylamine 

Relevant articles and documents

Low-toxicity amphiphilic molecules linked by an aromatic nucleus show broad-spectrum antibacterial activity and low drug resistance

Amphiphilic molecules linked by an aromatic nucleus were developed that showed high selectivity toward bacteria over mammalian cells, and low drug resistance. A promising compound 4g exhibited strong bactericidal activity against a panel of sensitive and resistant bacteria, low toxicity, the ability to reduce cell viability in biofilms, stability in mammalian fluids, rapid killing of pathogens, and high in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA).

Cyclic diamine compounds and medicine containing the same

The present invention offers novel cyclic diamine compounds and a pharmaceutical composition containing the same. The present invention relates to a compound represented by the formula (I) or salt(s) or solvate(s) thereof. (In the formula, is an optionally substituted divalent residue of benzene, pyridine, cyclohexane or naphthalene or is a vinylene group where Ar is an optionally substituted aryl group;X is —NH—, oxygen atom or sulfur atom;Y is —NR1—, oxygen atom, sulfur atom, sulfoxide or sulfone;Z is a single bond or —NR2—;R1 is hydrogen atom, optionally substituted lower alkyl group, optionally substituted aryl group or optionally substituted silyl lower alkyl group;R2 is hydrogen atom, optionally substituted lower alkyl group, optionally substituted aryl group or optionally substituted silyl lower alkyl group;l is an integer of from 0 to 15;m is an integer of 2 or 3; andn is an integer of from 0 to 3). The compound of the present invention is useful as a pharmaceutical composition, particuarly as an inhibitor of acyl coenzyme A cholesterol acyltransferase (ACAT).

NOVEL CYCLIC DIAMINE COMPOUNDS AND MEDICINE CONTAINING THE SAME

The present invention offers novel cyclic diamine compounds and a pharmaceutical composition containing the same. The present invention relates to a compound represented by the formula (I) or salt(s) or solvate(s) thereof. (In the formula, is an optionally substituted divalent residue of benzene, pyridine, cyclohexane or naphthalene or is a vinylene group whereAr is an optionally substituted aryl group;X is -NH-, oxygen atom or sulfur atom;Y is -NR1-, oxygen atom, sulfur atom, sulfoxide or sulfone;Z is a single bond or -NR2-;R1 is hydrogen atom, optionally substituted lower alkyl group, optionally substituted aryl group or optionally substituted silyl lower alkyl group;R2 is hydrogen atom, optionally substituted lower alkyl group, optionally substituted aryl group or optionally substituted silyl lower alkyl group;l is an integer of from 0 to 15;m is an integer of 2 or 3; andn is an integer of from 0 to 3).The compound of the present invention is useful as a pharmaceutical composition, particuarly as an inhibitor of acyl coenzyme A cholesterol acyltransferase (ACAT).