5464-44-8

Basic information

• Product Name: N-PHTHALOYL-DL-METHIONINE
• Synonyms: AKOS BBS-00006532;2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)-4-(METHYLTHIO)BUTANOIC ACID;2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)-4-(METHYLSULFANYL)BUTANOIC ACID;TIMTEC-BB SBB001859;PHT-DL-MET-OH;PHTHALYL-DL-METHIONINE;PHTHALOYL-DL-METHIONINE;N-PHTHALOYL-DL-METHIONINE
• CAS NO: 5464-44-8
• Molecular Formula: C₁₃H₁₃NO₄S
• Molecular Weight: 279.31
• Mol File: 5464-44-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 492°Cat760mmHg
• Flash Point: 251.4°C
• Appearance: /
• Density: 1.422g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-PHTHALOYL-DL-METHIONINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-PHTHALOYL-DL-METHIONINE(5464-44-8)
• EPA Substance Registry System: N-PHTHALOYL-DL-METHIONINE(5464-44-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 5464-44-8(Hazardous Substances Data)

Usage

General Description

N-Phthaloyl-DL-methionine is a chemical compound that is commonly used as a reactant in the synthesis of various pharmaceuticals and organic compounds. It is derived from the amino acid methionine and has a phthaloyl group attached to its nitrogen atom. N-PHTHALOYL-DL-METHIONINE has been studied for its potential applications in the treatment of various medical conditions, including kidney disease and certain types of cancer. It is known for its ability to chelate heavy metal ions, which makes it useful in industrial processes and environmental remediation. N-Phthaloyl-DL-methionine is considered to be relatively stable and safe to handle, with low toxicity reported in laboratory studies. Overall, this compound has a wide range of potential uses in both the pharmaceutical and industrial sectors.

Upstream product

• 85-44-9 phthalic anhydride 
• 59-51-8 DL-methionine 

Downstream Products

• 109541-75-5 methyl 1-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)cyclopropanecarboxylate 
• 55985-04-1 methyl (S)-4-methylsulfanyl-2-phthalimidobutanoate 
• 39739-05-4 methyl-(S)-2-phthalimido-4-methylthiobutanoate 
• 120831-43-8 N,N-phthaloyl-methionine-(N-diphenylacetyl-p-toluidide) 

Relevant articles and documents

Palladium-Catalyzed Decarbonylation of Amino Acid Derivatives via C-C Bond and C-N Bond Dual Activations

A unique decarbonylation of an amino acid derivative catalytic system has been established via palladium-catalyzed C-C bond and C-N bond dual activations. By employing 8-aminoquinoline as the directing group, this transformation has been found to facilitate the high chemoselectivity to decarbonylation of amino acid derivatives rather than intramolecular deamination or cross-dehydrogenative coupling reactions. This method provides a straightforward avenue for constructing diverse functionalized amide compounds in good to excellent yields. We proposed a possible reaction pathway that may go through the C-C bond and C-N bond dual activations on the basis of the mechanistic studies.