5465-04-3

Basic information

• Product Name: 2-Phenyl-4H-1-benzopyran-4-thione
• Synonyms: 2-Phenyl-4H-1-benzopyran-4-thione
• CAS NO: 5465-04-3
• Molecular Formula: C₁₅H₁₀OS
• Molecular Weight: 0
• EINECS: 226-765-2
• Mol File: 5465-04-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 369°C at 760 mmHg
• Flash Point: 177°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 2.6E-05mmHg at 25°C
• Refractive Index: 1.704
• CAS DataBase Reference: 2-Phenyl-4H-1-benzopyran-4-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenyl-4H-1-benzopyran-4-thione(5465-04-3)
• EPA Substance Registry System: 2-Phenyl-4H-1-benzopyran-4-thione(5465-04-3)

Safety Data

• Hazardous Substances Data: 5465-04-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H10OS/c17-15-10-14(11-6-2-1-3-7-11)16-13-9-5-4-8-12(13)15/h1-10H

Upstream product

• 525-82-6 FLAVONE 
• 19172-47-5 Lawessons reagent 
• 1469-94-9 1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione 
• 98-88-4 benzoyl chloride 
• 118-93-4 o-hydroxyacetophenone 
• 4010-33-7 2-acetylphenyl benzoate 
• 4388-05-0 diflavylene 

Downstream Products

• 60633-34-3 butyl-(2-phenyl-chromen-4-yliden)-amine 
• 19726-09-1 2-phenyl-chromen-4-one-phenylhydrazone 
• 4702-62-9 2-phenyl-chromen-4-one-hydrazone 
• 22115-89-5 Flavon-Oxim 
• 4388-05-0 2,2'-diphenyl-[4,4']bichromenylidene 
• 115053-52-6 [(C₆H₃)(OC₃H(S)(C₆H₅))ClPd]2 
• 56240-49-4 2-phenyl-chromen-4-one-(2,4-dinitro-phenylhydrazone) 
• 56429-97-1 bis-(2-phenyl-chromen-4-ylidene)-hydrazine 
• 19725-78-1 flavone thiosemicarbazone 
• 19726-08-0 2-phenyl-chromen-4-one acetylhydrazone 
• 7578-80-5 (2-phenyl-chromen-4-yliden)-aniline 
• 56240-49-4 N-(2,4-Dinitro-phenyl)-N'-[2-phenyl-chromen-(4E)-ylidene]-hydrazine 
• 14233-66-0 4,4'-biflav-2-ene 
• 525-82-6 FLAVONE 

Relevant articles and documents

Preparation of thioflavones via thiophosphoryl chloride mediated cyclodehydration and thionation of 1-(2-hydroxyphenyl)-3-arylpropane-1,3-diones

A simple and convenient one-pot strategy for the preparation of thioflavones from 1,3-diketones is described. Cyclodehydration of a range of β-diketones and thionation of the resulting flavones was achieved using thiophosphoryl chloride (PSCl3) which serves as both a catalyst and thionating agent. Georg Thieme Verlag Stuttgart · New York.

A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors

A new series of synthetic flavones, thioflavones, and flavanones has been synthesized and evaluated as potential inhibitors of monoamine oxidase isoforms (MAO-A and -B). The most active series is the flavanone one with higher selective inhibitory activity against MAO-B. Some of these flavanones (mainly the most effective) have been separated and tested as single enantiomers. In order to investigate the MAOs recognition of the most active and selective compounds, a molecular modeling study has been performed using available Protein Data Bank (PDB) structures as receptor models for docking experiments.

Synthesis and antibacterial activity of substituted flavones, 4-thioflavones and 4-iminoflavones

Synthesis of flavones, 4-thioflavones and 4-iminoflavones was carried out with the substitution of variable halogens, methyl, methoxy and nitro groups in the A, B and AB rings of the respective compounds and we also report here their antibacterial activity. Most of the synthesized compounds were found to be active against Escherichia coli, Bacillus subtilis, Shigella flexnari, Salmonella aureus, Salmonella typhi and Pseudomonas aeruginosa. Activity of 4-thioflavones and 4-iminoflavones was found to be higher than that of their corresponding flavone analogues. Investigated compounds having substituents like F, OMe and NO2 at 4′-position in ring-B exhibited enhanced activity and the presence of electronegative groups in the studied compounds showed a direct relationship to the antibacterial activity.