5465-43-0

Basic information

• Product Name: 1,3-bis(4-chlorophenyl)-4,7-dihydro-2-benzofuran
• CAS NO: 5465-43-0
• Molecular Formula: C₂₀H₁₄Cl₂O
• Molecular Weight: 341.2306
• Mol File: 5465-43-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 484.4°C at 760 mmHg
• Flash Point: 246.8°C
• Density: 1.278g/cm³
• Vapor Pressure: 4.54E-09mmHg at 25°C
• Refractive Index: 1.621
• CAS DataBase Reference: 1,3-bis(4-chlorophenyl)-4,7-dihydro-2-benzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(4-chlorophenyl)-4,7-dihydro-2-benzofuran(5465-43-0)
• EPA Substance Registry System: 1,3-bis(4-chlorophenyl)-4,7-dihydro-2-benzofuran(5465-43-0)

Safety Data

• Hazardous Substances Data: 5465-43-0(Hazardous Substances Data)

Usage

Classification

Diaryl ether

Use

Selective estrogen receptor modulator (SERM)

Approved for

Treatment and prevention of osteoporosis in postmenopausal women

Mechanism of Action

Binds to estrogen receptors in bone tissue, acting as an estrogen agonist

Effect on Bone

Increases bone mineral density and reduces the risk of fractures

Effect on Breast Tissue

Acts as an estrogen antagonist, leading to a decreased risk of breast cancer

Additional Potential Uses

Investigated for treating Alzheimer's disease and cardiovascular disease

Structure

Contains a benzofuran core with two 4-chlorophenyl groups attached at the 1,3 positions

Upstream product

• 86119-84-8 phosphoric acid 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 

Downstream Products

• 6315-71-5 1,3-bis-(4-chloro-phenyl)-isobenzofuran 
• 7477-14-7 1,2-bis-(4-chloro-benzoyl)-benzene