54660-78-5

Basic information

• Product Name: 5-AMINO-4-CHLOROPYRIMIDINE
• Synonyms: 5-AMINO-4-CHLOROPYRIMIDINE;5-PYRIMIDINAMINE, 4-CHLORO-;5-Pyrimidinamine, 4-chloro- (9CI);4-chloropyriMidin-5-aMine;4-Chloro-5-aMinopyriMidine;4-chloro-pyriMidin-5-ylaMine;4-Chloro-5-pyrimidinamine
• CAS NO: 54660-78-5
• Molecular Formula: C₄H₄ClN₃
• Molecular Weight: 129.55
• Product Categories: PYRIMIDINE;Heterocycle-Pyrimidine series
• Mol File: 54660-78-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 110-116℃
• Boiling Point: 253.8 °C at 760 mmHg
• Flash Point: 107.3 °C
• Appearance: White to pale brown/Solid
• Density: 1.437 g/cm³
• Vapor Pressure: 0.0179mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: 2-8°C
• PKA: 1.30±0.16(Predicted)
• Sensitive: Air & Light Sensitive
• CAS DataBase Reference: 5-AMINO-4-CHLOROPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-4-CHLOROPYRIMIDINE(54660-78-5)
• EPA Substance Registry System: 5-AMINO-4-CHLOROPYRIMIDINE(54660-78-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 54660-78-5(Hazardous Substances Data)

Usage

General Description

5-Amino-4-chloropyrimidine is a chemical compound with the molecular formula C4H4ClN3. It is a pyrimidine derivative with a chlorine atom in the fourth position of the pyrimidine ring. 5-AMINO-4-CHLOROPYRIMIDINE is used in various industries, including pharmaceuticals and agrochemicals, as a building block for the synthesis of other organic compounds. It has also been studied for its potential biological and pharmacological properties, including as a potential antiviral and anticancer agent. Additionally, 5-amino-4-chloropyrimidine is used as an intermediate in the synthesis of various pharmaceuticals and as a precursor in the production of herbicides and pesticides. Its versatility and wide range of applications make it an important chemical in the field of organic synthesis and industrial chemistry.

InChI:InChI=1/C4H4ClN3/c5-4-3(6)1-7-2-8-4/h1-2H,6H2

Upstream product

• 54851-35-3 4-chloro-5-amino-6-mercaptopyrimidine 
• 54851-35-3 5-amino-6-chloro-3H-pyrimidine-4-thione 

Downstream Products

• 59447-72-2 4-chloro-N-methylpyrimidine-5-amine 
• 1437789-99-5 2-(4-chloropyrimidin-5-yl)isoindoline-1,3-dione 
• 918880-63-4 4-chloro-N-(4-chloro-5-pyrimidinyl)-3-cyanobenzamide 
• 57417-53-5 5-amino-3H-pyrimidine-4-thione 

Relevant articles and documents

Kinase inhibitor, and preparation and application of kinase inhibitor

The invention provides a compound shown as a formula (I), or a stereoisomer, a tautomer, nitrogen oxide, metabolite, a prodrug, pharmaceutically acceptable salt or solvate of the compound, and application of the compound to preparing drugs or drug compositions for treating Pim kinase-mediated diseases.

Multimeric VLA-4 antagonists comprising polymer moieties

Disclosed are conjugates which bind VLA-4. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such conjugates are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The conjugates can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.