5467-69-6

Basic information

• Product Name: 2-METHOXY-5-NITRO-6-PICOLINE
• Synonyms: 6-Methoxy-3-nitro-2-methylpyridine;2-METHOXY-5-NITRO-6-METHYLPYRIDINE;2-METHOXY-5-NITRO-6-PICOLINE (2-METHOXY-6-METHYL-5-NITROPYRIDINE);6-methoxy-2-methyl-3-nitropyridine;2-Methyl-3-nitro-6-methyoxypyridine;2-Methoxy-5-nitropyridine;6-Metho×y-2-Methyl-3-nitropyridine;6-Methoxy-2-Methyl-3-nitro-pyridin
• CAS NO: 5467-69-6
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.15
• Product Categories: Pyridines;Boronic Acid;Pyridine
• Mol File: 5467-69-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 104-108 ºC
• Boiling Point: 261.1 °C at 760 mmHg
• Flash Point: 111.7 °C
• Appearance: /
• Density: 1.247 g/cm³
• Vapor Pressure: 3.73E-16mmHg at 25°C
• Refractive Index: 1.84
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 0.09±0.10(Predicted)
• CAS DataBase Reference: 2-METHOXY-5-NITRO-6-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-5-NITRO-6-PICOLINE(5467-69-6)
• EPA Substance Registry System: 2-METHOXY-5-NITRO-6-PICOLINE(5467-69-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• Hazardous Substances Data: 5467-69-6(Hazardous Substances Data)

Usage

General Description

2-Methoxy-5-nitro-6-picoline is a chemical compound with the molecular formula C7H7N2O3. It is a derivative of picoline, a type of pyridine compound, and contains a nitro group and a methoxy group. 2-METHOXY-5-NITRO-6-PICOLINE is used in organic synthesis and as a building block in the production of pharmaceuticals, dyes, and agrochemicals. It has also been studied for its potential biological and pharmacological properties, including its ability to interact with receptors in the central nervous system. 2-Methoxy-5-nitro-6-picoline is considered to have potential applications in the fields of medicinal chemistry and drug development.

InChI:InChI=1/C21H12I2N2O/c22-12-3-7-15-16-8-4-13(23)10-18(16)20-19(17(15)9-12)24-21(25-20)11-1-5-14(26)6-2-11/h1-10,24-25H

Upstream product

• 67-56-1 methanol 
• 22280-60-0 6-chloro-4-methyl-3-nitropyridine 
• 5446-92-4 2-methoxy-5-nitropyridine 
• 16427-42-2 methanesulfonic acid 2,2-dimethyl-propyl ester 
• 28489-45-4 6-methyl-5-nitropyridin-2(1H)-one 
• 124-41-4 sodium methylate 
• 823-96-1 Trimethylboroxine 
• 63071-03-4 2-methoxy-6-methyl-pyridine 
• 22280-62-2 6-methyl-5-nitro-2-pyridinamine 
• 28489-45-4 6-methyl-5-nitropyridin-2-ol 

Downstream Products

• 28489-45-4 6-methyl-5-nitropyridin-2-ol 
• 42309-15-9 2,6-Dibrom-1,5-naphthyridin 
• 17288-33-4 5-methoxy-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid 
• 17322-90-6 ethyl 5-methoxy-1H-pyrrolo[3,2-b]pyridine-2-carboxylate 
• 1198085-41-4 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((6-methyl-5-nitropyridin-2-yloxy)methyl) isoxazole 
• 1027068-77-4 5-oxo-4,5-dihydro-1H-pyrrolo<3,2-b>pyridine-3-carbaldehyde 
• 17288-55-0 3-formyl-5-methoxy-1H-pyrrolo<3,2-b>pyridine 
• 17288-40-3 5-methoxy-4-aza-1H-indole 
• 52090-56-9 3-amino-6-methoxy-2-methylpyridine 

Relevant articles and documents

Alkylation of Nitropyridines via Vicarious Nucleophilic Substitution

Electrophilic nitropyridines react with sulfonyl-stabilized carbanions to give products of C-H alkylation via vicarious nucleophilic substitution. The process consists of formation of the Meisenheimer-type adduct followed by base-induced β-elimination of the sulfinic acid (e.g., PhSO2H). Mechanistic studies reveal that in the latter step alkyl substituent and adjacent nitro group tend to planarize for effective stabilization of benzyl anion, and thus, adduct of hindered isopropyl carbanion remains stable toward elimination for steric reasons.

INHIBITORS OF JANUS KINASES

The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3, TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE

Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.