54752-32-8

Basic information

• Product Name: 1(2H)-Naphthalenone, 3,4-dihydro-2-[(2-methylphenyl)methylene]-
• CAS NO: 54752-32-8
• Molecular Formula: C18H16O
• Molecular Weight: 248.324
• Mol File: 54752-32-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1(2H)-Naphthalenone, 3,4-dihydro-2-[(2-methylphenyl)methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Naphthalenone, 3,4-dihydro-2-[(2-methylphenyl)methylene]-(54752-32-8)
• EPA Substance Registry System: 1(2H)-Naphthalenone, 3,4-dihydro-2-[(2-methylphenyl)methylene]-(54752-32-8)

Safety Data

• Hazardous Substances Data: 54752-32-8(Hazardous Substances Data)

Upstream product

• 89-95-2 2-methyl-benzyl alcohol 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 529-20-4 2-methylphenyl aldehyde 
• 771-29-9 1,2,3,4-tetrahydro-1-naphthyl hydroperoxide 

Downstream Products

• 1379762-76-1 (2R,3'S)-3'-(2-methphenyl)-3,4-dihydro-1H-spiro[naphthalene-2,2'-oxiran]-1-one 

Relevant articles and documents

Copper/GanPhos-Catalyzed 1,3-Dipolar Cycloaddition of Azo?-methine Ylides: An Efficient Access to Chiral Pyrrolidine Spirocycles

A highly efficient copper/GanPhos-catalyzed 1,3-dipolar cyclo?-addition?-of azomethine ylides is reported. This viable transformation provides a series of optically active spiro[dihydronaphthalene-2,3′-pyrrolidine]s, bearing one spiro quaternary and three tertiary stereogenic centers, in good yields and with high ee values. This protocol features high diastereo- A nd enantioselectivity, broad substrate scope and mild reaction conditions.

A simple iron-catalyst for alkenylation of ketones using primary alcohols

Herein, we developed a simple iron-catalyzed system for the α-alkenylation of ketones using primary alcohols. Such acceptor-less dehydrogenative coupling (ADC) of alcohols resulted in the synthesis of a series of important α,β-unsaturated functionalized ketones, having aryl, heteroaryl, alkyl, nitro, nitrile and trifluoro-methyl, as well as halogen moieties, with excellent yields and selectivity. Initial mechanistic studies, including deuterium labeling experiments, determination of rate and order of the reaction, and quantitative determination of H2 gas, were performed. The overall transformations produce water and dihydrogen as byproducts.

Basic Anion-Exchange Resin-Catalyzed Aldol Condensation of Aromatic Ketones with Aldehydes in Continuous Flow

A general method for the aldol condensation of aromatic ketones with aldehydes was developed under continuous-flow conditions using a commercially available, strongly basic anion-exchange resin (A26) as catalyst. This procedure, in addition to exhibiting a wide substrate scope, promoted carbon-carbon bond formation under mild conditions using a quasi-stoichiometric ratio of starting reagents with good to excellent yields, thereby forming a limited amount of waste and allowing the process to be applied to sequential-flow systems. A proof of concept was developed in the first fully heterogeneously catalyzed two-step flow synthesis of donepezil, which is a blockbuster commercial anti-Alzheimer's drug.