54796-53-1

Basic information

• Product Name: 5-Bromo-4-methylthiophene-2-carboxylic acid
• Synonyms: 5-Bromo-4-methylthiophene-2-carboxylic acid
• CAS NO: 54796-53-1
• Molecular Formula: C₆H₅BrO₂S
• Molecular Weight: 221.07
• Mol File: 54796-53-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 322.448 °C at 760 mmHg
• Flash Point: 148.812 °C
• Appearance: /
• Density: 1.784 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.57±0.10(Predicted)
• CAS DataBase Reference: 5-Bromo-4-methylthiophene-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-4-methylthiophene-2-carboxylic acid(54796-53-1)
• EPA Substance Registry System: 5-Bromo-4-methylthiophene-2-carboxylic acid(54796-53-1)

Safety Data

• Hazardous Substances Data: 54796-53-1(Hazardous Substances Data)

Usage

General Description

5-Bromo-4-methylthiophene-2-carboxylic acid is a chemical compound with the molecular formula C7H5BrO2S. It is a derivative of thiophene, a five-membered heterocyclic compound containing four carbon atoms and one sulfur atom. 5-Bromo-4-methylthiophene-2-carboxylic acid contains a bromine atom, a methyl group, and a carboxylic acid functional group attached to the thiophene ring. It is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its potential biological activity and ability to modify the properties of other organic molecules. It is also used as a building block in organic synthesis, particularly in the development of new materials and pharmaceuticals.

InChI:InChI=1/C6H5BrO2S/c1-3-2-4(6(8)9)10-5(3)7/h2H,1H3,(H,8,9)

Upstream product

• 14282-76-9 2-bromo-3-methylthiophene 
• 7758-19-2 sodium chlorite 
• 189331-47-3 5-bromo-4-methyl-2-thiophene carboxaldehyde 
• 4885-02-3 Dichloromethyl methyl ether 
• 54796-47-3 5-bromo-4-methyl-2-thiophenecarboxylic acid methyl ester 
• 14282-78-1 4-methylthiophene-2-carboxylic acid 

Downstream Products

• 54796-47-3 5-bromo-4-methyl-2-thiophenecarboxylic acid methyl ester 

Relevant articles and documents

Novel ASK1 inhibitor and application thereof

The invention relates to a compound shown as a general formula (I), a pharmacologically acceptable salt, ester or a stereisomer. The invention also relates to a preparation method of the compound, a medicine preparation containing the compound and a medic

USEFUL THIOPHENE DERIVATIVES IN THE TREATMENT OF DIABETES

The present invention relates to a thiophene derivative of the following general formula I or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt thereof or to its use as a drug in particular intended for treating and/or preventing diabetes, its complications and/or associated pathologies, advantageously diabetes of type II and hyperglycemia.

CYSTEINE PROTEASE INHIBITORS

A compound of the formula (II) wherein one of R1 and R2 is halo and the other is H or halo; R3 is C1-C4 straight or branched chain, optionally fluorinated, alkyl; R4 is H; or R3 together with R4 and the adjoining backbone carbon defines: a spiro-C5-C7 cycloalkyl, optionally substituted with 1 to 3 substituents selected from halo, hydroxyl, C1-C4 alkyl or C1-C4 haloalkyl; or optionally bridged with a methylene group; or a C4-C6 saturated heterocycle having a hetero atom selected from O, NRa, S, S(=O)2 ; where Ra is H, C1-C4 alkyl or CH3C(=O); R5 is independently selected from H or methyl; E is -C(=O)-, -S(=O)m-, -NR5S(=O)m-, -NR5C(=O)-, -OC(=O)-, R6 is a stable, optionally substituted, monocyclic or bicyclic, carbocycle or hetorocycle; m is independently 0,1 or 2; are inhibitors of cathepsin K and useful in the treatment or prophylaxis of osteoporosis.