548-25-4 Usage
Complex organic compound
The compound has a complex structure composed of multiple elements and functional groups.
Xanthene core
The central structure of the compound is a xanthene, which is an organic compound containing a fused ring of four carbon atoms.
Benzoic acid side chain
The compound has a side chain of benzoic acid, which is a simple aromatic acid.
Fluorescent dye
The compound exhibits fluorescent properties, meaning it can absorb light at one wavelength and emit light at a longer wavelength.
pH indicator
The compound can be used to indicate changes in pH levels, as it changes color in response to changes in the acidity or basicity of a solution.
Biological stain
The compound can be used to stain biological samples, such as cells or tissues, to make them more visible under a microscope.
Multiple iodine atoms
The compound contains four iodine atoms, which contribute to its distinctive fluorescent properties.
Hydroxyl group
The compound has a hydroxyl (-OH) functional group, which provides reactivity and allows the compound to interact with other molecules.
Ketone functional group
The compound has a ketone (C=O) functional group, which provides solubility in different solvents and contributes to its reactivity.
Diverse applications
The compound has a wide range of applications in chemical and biological research, including as a pH indicator, biological stain, and fluorescent probe.
Versatility
The compound's unique properties make it a valuable tool in various scientific disciplines, including chemistry, biology, and medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 548-25-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,4 and 8 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 548-25:
(5*5)+(4*4)+(3*8)+(2*2)+(1*5)=74
74 % 10 = 4
So 548-25-4 is a valid CAS Registry Number.
548-25-4Relevant articles and documents
Rose Bengal analogs and vesicular glutamate transporters (VGLUTs)
Pietrancosta, Nicolas,Kessler, Albane,Favre-Besse, Franck-Cyril,Triballeau, Nicolas,Quentin, Thomas,Giros, Bruno,Mestikawy, Salah El,Acher, Francine C.
experimental part, p. 6922 - 6933 (2010/10/19)
Vesicular glutamate transporters (VGLUTs) allow the loading of presynaptic glutamate vesicles and thus play a critical role in glutamatergic synaptic transmission. Rose Bengal (RB) is the most potent known VGLUT inhibitor (K i 25 nM); therefore we designed, synthesized and tested in brain preparations, a series of analogs based on this scaffold. We showed that among the two tautomers of RB, the carboxylic and not the lactonic form is active against VGLUTs and generated a pharmacophore model to determine the minimal structure requirements. We also tested RB specificity in other neurotransmitter uptake systems. RB proved to potently inhibit VMAT (Ki 64 nM) but weakly VACHT (Ki >9.7 μM) and may be a useful tool in glutamate/acetylcholine co-transmission studies.
