548-83-4 Usage
Description
Galangin, a flavonoid belonging to the Zingiberaceae family, is naturally found in herbs such as Alpinia officinarum, galangal rhizome (Alpinia galanga), and propolis. It possesses potent antioxidant and anti-inflammatory properties, making it a valuable component in traditional medicine. Galangin also acts as an antagonist of the aryl hydrocarbon receptor, inducing apoptosis in cancer cells and inhibiting cytochrome P450 isoform 1A1.
Used in Pharmaceutical Industry:
Galangin is used as a CYP1A1 inhibitor for its ability to inhibit cytochrome P450 isoform 1A1 with an IC50 value of less than 1 μM.
Used in Cancer Treatment:
Galangin is used as an anticancer agent for its ability to inhibit the proliferation of estrogen receptor-positive MCF-7 human breast cancer cells and delay mammary tumorigenesis.
Used in Herbal Medicine:
Galangin is used as a vasodilator and for its anti-inflammatory actions related to the suppression of signaling through NF-κB in mice.
Used in Antioxidant Applications:
Galangin is used as a potent antioxidant due to its flavonoid properties, which contribute to its beneficial effects in traditional medicine.
Biochem/physiol Actions
Galangin exhibits antioxidant, anti-apoptotic, anti-inflammatory and anti-obesity properties. In addition, it also possesses anti-genotoxic activity against environmental and dietary carcinogens. Galangin inhibits cancer growth by hindering cancer cell proliferation, induction of apoptosis and autophagy and inhibition of metastasis. Galangin also has an ability to inhibit CYP1A1 (Cytochrome P450, family 1, member A1) activity.
Anticancer Research
Galangin is a flavonol that is derived from Alpinia officinarum, a plant from the gingerfamily, grown in Southeast Asia. The extract from the rhizome suppresses cellproliferation of hepatocellular carcinoma cells (Su et al. 2013). ER stress is inducedby galangin as is evident by rise in concentration of cytosolic Ca2+ and other UPRtarget genes like CHOP, GRP 78 and GRP 94. The ER is a major storage site forintracellular calcium. Normal functioning of ER chaperones is disrupted by calciumexhaustion in ER which produces ER stress and hence activation of UPR (Hotamisligil2010; Mekahli et al. 2011). CHOP and 4-polybutyric acid siRNA, well-known ERstress inhibitor, substantially blocked stress induced by galangin in the HCC cell line.To sum up, ER stress is upregulated by galangin, inhibiting cancer cell proliferation,and galangin can prove to be an effective anticancer agent (Su et al. 2013).
Check Digit Verification of cas no
The CAS Registry Mumber 548-83-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,4 and 8 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 548-83:
(5*5)+(4*4)+(3*8)+(2*8)+(1*3)=84
84 % 10 = 4
So 548-83-4 is a valid CAS Registry Number.
InChI:InChI=1/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
548-83-4Relevant articles and documents
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Chawla,Chibber
, p. 2171 (1976)
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An effective synthesis of 3-methoxyflavones via 1-(2-hydroxyphenyl)-2- methoxy-3-phenyl-1,3-propanediones
Lee, Jae In,Park, Se Bin
scheme or table, p. 1379 - 1382 (2012/07/02)
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Tannins, flavonol sulfonates, and a norlignan from Phyllanthus virgatus
Huang, Yu-Lin,Chen, Chien-Chih,Hsu, Feng-Lin,Chen, Chieh-Fu
, p. 1194 - 1197 (2007/10/03)
Investigation of the constituents of Phyllanthus virgatus has led to the isolation of five new compounds, including a norlignan, 2-(3,4- methylenedioxybenzyl)-4-(3,4-methylenedioxyphenyl)-3-butyne-1,2-diol named virgatyne (1); a hydrolyzable tannin, virganin (2); and three flavonoid sulfonates, galangin-8-sulfonate (4), galangin-3-O-β-D-glucoside-8- sulfonate (5), and kaempferol-8-sulfonate (6). Their structures were established by spectral and chemical methods.