54852-68-5

Basic information

• Product Name: 2-Methyl-4-chloro-6-bromophenol
• Synonyms: 2-Bromo-4-chloro-6-methylphenol;2-Methyl-4-chloro-6-bromophenol
• CAS NO: 54852-68-5
• Molecular Formula: C₇H₆BrClO
• Molecular Weight: 221.48
• EINECS: 201-805-1
• Mol File: 54852-68-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 51-52 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 247.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.674±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 8.34±0.23(Predicted)
• CAS DataBase Reference: 2-Methyl-4-chloro-6-bromophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-4-chloro-6-bromophenol(54852-68-5)
• EPA Substance Registry System: 2-Methyl-4-chloro-6-bromophenol(54852-68-5)

Safety Data

• Hazardous Substances Data: 54852-68-5(Hazardous Substances Data)

Usage

General Description

2-Methyl-4-chloro-6-bromophenol is a chemical compound with the molecular formula C7H6BrClO. It is a phenolic compound with a substituent of a methyl group, a chlorine atom, and a bromine atom attached to the phenol ring. 2-Methyl-4-chloro-6-bromophenol is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a chemical intermediate in the production of dyes and perfumes. 2-Methyl-4-chloro-6-bromophenol is known for its strong odor and is considered to be a toxic and harmful substance, requiring proper handling and disposal.

Upstream product

• 1570-64-5 2-methyl-4-chlorophenol 
• 1972-28-7 diethylazodicarboxylate 
• 2446-83-5 di-isopropyl azodicarboxylate 

Downstream Products

• 869085-32-5 2-bromo-4-chloro-6-methylphenyl 2-propenyl ether 

Relevant articles and documents

UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF

Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of USP7 activity.

Regioselective bromination of activated aromatic substrates with a ZrBr4/diazene mixture

A regioselective method for the bromination of phenols, ethers and anilines using a ZrBr4/diazene mixture is described. The reaction takes place under mild reaction conditions and the bromine atom adds first at the para unsubstituted position with respect to the OH, OR or NR2 group of the activated aromatic substrate. Less reactive compounds such as toluene, phenyl acetate, benzonitrile and trifluoromethylbenzene remain intact under the same conditions.

Solid state nuclear bromination with N-bromosuccinimide. Part 1. Experimental and theoretical studies on some substituted aniline, phenol and nitro aromatic compounds

Solid state bromination of a number of substituted phenol, aniline and nitro aromatic compounds with N-bromosuccinimide yields exclusively the nuclear brominated products. Reactivity in the solid state depends on the reaction time, temperature and nature of the substituent on the substrate. The reaction apparently proceeds by an electrophilic aromatic substitution pathway. Molecular orbital and reaction free energy calculations also support such a view. Thermal analysis and video microscopic observation reveal the nature of the solid state reaction. Crystallinity is required for the reactivity and product selectivity. Product yield decreases with loss of selectivity when the reaction is carried out in a melt or in solution. Unlike the topochemical solid state reactions wherein molecular packing is more important than the intrinsic reactivity, these reactions demonstrate the importance of both these factors.