548797-52-0

Basic information

• Product Name: 3-amino-6-(4-hydroxyphenyl)-1H-indazole
• Synonyms: 3-amino-6-(4-hydroxyphenyl)-1H-indazole
• CAS NO: 548797-52-0
• Molecular Weight: 225.25
• Mol File: 548797-52-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-amino-6-(4-hydroxyphenyl)-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-6-(4-hydroxyphenyl)-1H-indazole(548797-52-0)
• EPA Substance Registry System: 3-amino-6-(4-hydroxyphenyl)-1H-indazole(548797-52-0)

Safety Data

• Hazardous Substances Data: 548797-52-0(Hazardous Substances Data)

Upstream product

• 136285-77-3 4-hydroxy-3-chloro-4-cyanobiphenyl 
• 1257211-58-7 tert-butyl 3-amino-6-bromo-1H-indazole-1-carboxylate 
• 404827-77-6 ethyl 3-(3-(cyclopropanecarboxamido)-1H-indazol-6-yl)benzoate 
• 873426-76-7 tert-butyldimethylsilyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl ether 

Relevant articles and documents

Synthesis and SAR studies of 3,6-disubstituted indazole derivatives as potent hepcidin production inhibitors

Hepcidin has emerged as the central regulatory molecule of systemic iron homeostasis. Inhibition of hepcidin could be a strategy favorable to treating anemia of chronic disease (ACD). We report herein the synthesis and structure-activity relationships (SARs) of a series of indazole compounds as hepcidin production inhibitors. The optimization study of compound 1 led to a potent hepcidin production inhibitor 45, which showed serum hepcidin lowering effects in a mouse IL-6 induced acute inflammatory model.

6-Heteroaryl-pyrazolo[3,4-b]pyridines: Potent and selective inhibitors of Glycogen Synthase Kinase-3 (GSK-3)

A series of 6-heteroaryl-pyrazolo[3,4-b]pyridines has been optimised to afford potent inhibitors of Glycogen Synthase Kinase-3 (GSK-3). These analogues display excellent selectivity over the closely related Cyclin Dependant Kinase-2 (CDK-2).