55-36-7

Basic information

• Product Name: Histamine, monohydrochloride
• CAS NO: 55-36-7
• Molecular Formula: C₅H₁₀ClN₃
• Molecular Weight: 147.608
• Mol File: 55-36-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Histamine, monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Histamine, monohydrochloride(55-36-7)
• EPA Substance Registry System: Histamine, monohydrochloride(55-36-7)

Safety Data

• Hazardous Substances Data: 55-36-7(Hazardous Substances Data)

Usage

General Description

Histamine monohydrochloride is a chemical compound that is derived from histamine, which is a naturally occurring compound in the body. It is commonly used in pharmaceuticals and research as a tool to study the effects of histamine on the body. Histamine monohydrochloride acts as a mediator in allergic reactions and inflammatory responses by binding to specific receptors on various cells in the body. It also plays a role in regulating certain physiological functions such as gastric acid secretion and neurotransmission. In some cases, synthetic forms of histamine monohydrochloride are used in the treatment of conditions such as histamine intolerance and allergic reactions. Overall, histamine monohydrochloride is an important compound for studying histamine function and for its potential therapeutic uses.

Upstream product

• 71-00-1 L-histidine 
• 51-45-6 histamine 
• 71-00-1 L-histidine 

Downstream Products

• 913510-33-5 N-<ω-(benzyloxyamino)hexanoyl>histamine 
• 7271-14-9 [2-(3H-imidazol-4-yl)-ethyl]-(4-methoxy-benzylidene)-amine 
• 6882-74-2 4,5,6,7-tetrahydro-1H-imidazo<4,5-c>pyridine 
• 1494077-83-6 N-(2-(1H-imidazol-5-yl)ethyl)-2-(2-chlorophenoxy)acetamide 
• 1448991-61-4 C₂₁H₁₉N₃O₆ 
• 1364253-98-4 C₂₉H₃₇N₁₁O₄ 
• 1364254-00-1 C₃₉H₅₄N₁₂O₉ 
• 1357261-15-4 4-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine 
• 1265877-12-0 (+)-(S)-N-[2-(1H-Imidazol-4-yl)ethyl]-1-phenyl-2-propen-1-amine 
• 1248588-79-5 (E)-N-(2-(1H-imidazol-5-yl)ethyl)-3-(3,5-dibromo-4-methoxyphenyl)-2-(4-methoxybenzyloxyimino)propanamide 
• 74294-60-3 NO-bis-p-tolylsulphonylhistaminol 
• 74294-62-5 4-(2-Azido-ethyl)-1-(toluene-4-sulfonyl)-1H-imidazole 
• 74294-66-9 Phenyl-carbamic acid 2-(1H-imidazol-4-yl)-ethyl ester 

Relevant articles and documents

Synthesis method of high-purity histamine dihydrochloride

The invention discloses a synthesis method of high-purity histamine dihydrochloride, and belongs to the technical field of organic synthesis. The method comprises the steps: in a solvent A, carrying out a decarboxylation reactionon L-histidine at the temperature of 110-150 DEG C under the effect of a composite decarboxylation catalyst, and carrying out filtering after the reaction is completed, wherein the composite decarboxylation catalyst is composed of a main catalyst and an auxiliary catalyst, the main catalyst is selected from sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, pyridine, 4-methylpyridine, aniline, 4-methylaniline, ,N,N-dimethylaniline and N, N-dimethylformamide, and the auxiliary catalyst is one selected from benzophenone, acetophenone, benzophenone and p-methyl acetophenone; carrying out reduced pressure distillation on a filtrate, adding water into residues, and adjusting the pH value to 5-6 by using hydrochloric acid to obtain an aqueous solution; extracting the aqueous solution at least once by using an extracting agent to remove impurities; and evaporating to remove water in the aqueous solution, pulping with a solvent B, filtering and drying to obtain the product.

Synthetic method of histamine dichloride

The invention discloses a synthetic method of histamine dichloride, and belongs to the field of drug synthesis. The synthetic method comprises the following steps: preparing a cyano methylimidazole intermediate through oxidization of TCCA (Trichloroisocyanuric Acid) under an alkaline condition by taking L-histidine as an original raw material, and then preparing medicinal histamine dichloride through catalytic hydrogenation and one-step salifying process. In the histamine dichloride compounded through the synthetic method, the content of related substances is less than 0.5 percent, the content of a single impurity is less than 0.1 percent, and the histamine dichloride accords with medicinal level. A reagent adopted by the technology is cheap and of low-toxicity, the reaction is safe and reliable, an alcohol solvent can be recycled, after-treatment operation is simple and convenient, and the technology is environment-friendly and is beneficial for large-scale industrial production.