550-79-8

Basic information

• Product Name: 4',6-DIMETHOXY-7-HYDROXYISOFLAVONE
• Synonyms: 7-HYDROXY-4',6-DIMETHOXYISOFLAVONE;AFROMOSIN;4',6-DIMETHOXY-7-HYDROXYISOFLAVONE;7-Hydroxy-3-(4-methoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one;7-Hydroxy-6-methoxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one;Afrormosin;4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)-6-methoxy-;Aids027673
• CAS NO: 550-79-8
• Molecular Formula: C₁₇H₁₄O₅
• Molecular Weight: 298.29
• Product Categories: Iso-Flavones
• Mol File: 550-79-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 516°Cat760mmHg
• Flash Point: 193.6°C
• Appearance: /
• Density: 1.321g/cm³
• Vapor Pressure: 2.86E-11mmHg at 25°C
• Refractive Index: 1.621
• CAS DataBase Reference: 4',6-DIMETHOXY-7-HYDROXYISOFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4',6-DIMETHOXY-7-HYDROXYISOFLAVONE(550-79-8)
• EPA Substance Registry System: 4',6-DIMETHOXY-7-HYDROXYISOFLAVONE(550-79-8)

Safety Data

• Hazardous Substances Data: 550-79-8(Hazardous Substances Data)

Usage

Description

4',6-DIMETHOXY-7-HYDROXYISOFLAVONE is a methoxyisoflavone compound characterized by the presence of methoxy groups at positions 6 and 4', along with a hydroxy group at position 7. It is a naturally occurring flavonoid that can be found in various plant sources and has been the subject of research due to its potential biological activities.

Uses

Used in Pharmaceutical Industry:
4',6-DIMETHOXY-7-HYDROXYISOFLAVONE is used as a pharmaceutical compound for its potential therapeutic properties. 4',6-DIMETHOXY-7-HYDROXYISOFLAVONE has been studied for its antioxidant, anti-inflammatory, and anticancer activities, making it a promising candidate for the development of new drugs targeting various diseases.
Used in Nutraceutical Industry:
In the nutraceutical industry, 4',6-DIMETHOXY-7-HYDROXYISOFLAVONE is used as a dietary supplement due to its antioxidant and anti-inflammatory properties. It may contribute to the overall health and well-being of individuals by providing additional support for the immune system and reducing the risk of chronic diseases.
Used in Cosmetic Industry:
4',6-DIMETHOXY-7-HYDROXYISOFLAVONE is also used in the cosmetic industry as an active ingredient in skincare products. Its antioxidant and anti-inflammatory properties can help protect the skin from environmental stressors, reduce inflammation, and promote a healthy, youthful appearance.
Used in Agricultural Industry:
In the agricultural industry, 4',6-DIMETHOXY-7-HYDROXYISOFLAVONE may be utilized as a natural pesticide or growth promoter due to its potential biological activities. It could be an environmentally friendly alternative to synthetic chemicals, contributing to sustainable agricultural practices.

InChI:InChI=1/C17H14O5/c1-20-11-5-3-10(4-6-11)13-9-22-15-8-14(18)16(21-2)7-12(15)17(13)19/h3-9,18H,1-2H3

Upstream product

• 171364-79-7 2-(4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 5128-54-1 1-(2,4-dihydroxy-5-methoxyphenyl)-2-(4-methoxyphenyl)ethanone 
• 68-12-2 N,N-dimethyl-formamide 
• 17817-31-1 6,7,4'-trihydroxyisoflavone 
• 897-46-1 6,7-dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one 
• 290-87-9 1,3,5-Triazine 
• 104-47-2 p-methoxybenzylnitrile 
• 6100-60-3 4-methoxybenzene-1,3-diol 

Downstream Products

• 128885-10-9 7-hydroxy-4',6-dimethoxyisoflavane 
• 4253-19-4 6-methoxy-3-(4-methoxyphenyl)4-oxo-4H-chromen-7-yl acetate 
• 936257-08-8 [6-Methoxy-3-(4-methoxy-phenyl)-4-oxo-4H-chromen-7-yloxy]-acetic Acid Methyl Ester 
• 101110-83-2 2,4-Dihydroxy-5,4'-dimethoxy-benzil 
• 5128-54-1 1-(2,4-dihydroxy-5-methoxyphenyl)-2-(4-methoxyphenyl)ethanone 

Relevant articles and documents

Invention relates to a soybean in the process of synthesis method

The present invention relates to organic chemical and technical field of drug synthesis, relates to a soybean flavins and its analogue synthetic method, the soybean flavins that 6 - methoxy - 4', 7 - dihydroxy isoflavone. The invention push-type apparatus shown synthetic route, to synthesize soybean flavins that 6 - methoxy - 4', 7 - dihydroxy isoflavone and its analogs, synthetic route of the present invention high yield, the operation is simple, mild condition, suitable for large-scale preparation.

Isolation of isoflavones from Iris kashmiriana Baker as potential anti proliferative agents targeting NF-kappaB

Cancer is possibly one of the most devastating and complex disease and therefore involves chemotherapy as one of the frontline strategies in its therapy. However, expected toxicity and resistance with chemotherapeutic agents encourage us to use the plant derived natural chemotherapeutic sources at the clinical stage of cancer therapy. In view of this strategy, herein new glycosides and isoflavonoids were isolated from Iris kashmiriana Baker and subjected to structure elucidation followed by their biological evaluation. Isolated compounds and their derivatives were purified by the column chromatography and structural identification was made by a combination of various spectroscopic technique vis. UV, IR, 1H NMR, 13C NMR, DEPT, 2-D NMR and mass spectrometry coupled with chemical analysis. Furthermore, an in silico library of isolated isoflavones and its analogues were designed. NF-kappaB (transcription factor that facilitates angiogenesis, inflammation, invasion and metastasis) was selected as a target to evaluate the anticancer and antioxidant activity of isoflavones and its analogues. Designed library of isoflavones and analogues were docked into the active site of NF-kappa B and the most active 15 analogues were selected for synthesis. Finally, all compounds were evaluated for their cytotoxicity against various cell lines and antioxidant activity with different methods that demonstrate their anti-cancer and anti-oxidant potential. The cell cycle specificity of the cytotoxicity was further analyzed by corresponding analysis, using flow cytometer. Most of the compounds exhibit moderate activity, whereas the 5,7,8-trihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one, 5,7,8-trihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one, 5,7,8-triacetoxyoxy-3-(4-methoxyphenyl)-4H-chromen-4-one and 6,7-diacetoxyoxy-3-(4-methoxyphenyl)-4H-chromen-4-one showed distinct broad-spectrum anticancer activity with IC50 values ranges between 3.8 and 5.6?μg/mL. Cell cycle analysis indicates that these compounds induced cell cycle arrest at G2/M phase.

Isoflavon-Synthese mit 1,3,5-Triazin

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