55030-49-4

Basic information

• Product Name: (3-Methoxyphenyl)2-pyridinylmethanone
• Synonyms: (3-Methoxyphenyl)2-pyridinylmethanone
• CAS NO: 55030-49-4
• Molecular Formula: C₁₃H₁₁NO₂
• Molecular Weight: 213.24
• Mol File: 55030-49-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 370.811°C at 760 mmHg
• Flash Point: 178.06°C
• Appearance: /
• Density: 1.154g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: (3-Methoxyphenyl)2-pyridinylmethanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3-Methoxyphenyl)2-pyridinylmethanone(55030-49-4)
• EPA Substance Registry System: (3-Methoxyphenyl)2-pyridinylmethanone(55030-49-4)

Safety Data

• Hazardous Substances Data: 55030-49-4(Hazardous Substances Data)

Usage

General Description

(3-Methoxyphenyl)2-pyridinylmethanone, also known as MPMP, is a chemical compound with the molecular formula C13H11NO2. It is a synthetic organic compound with potential applications in the pharmaceutical industry, particularly in the development of new drugs. MPMP has been the subject of research for its potential bioactivity and pharmacological effects, as well as its potential use as a building block for the synthesis of other compounds. Its chemical structure consists of a pyridine ring attached to a ketone group and a methoxyphenyl substituent, which provides opportunities for diverse chemical reactions and potential biological interactions. Further studies and research are needed to fully understand the properties and potential applications of (3-Methoxyphenyl)2-pyridinylmethanone.

InChI:InChI=1/C13H11NO2/c1-16-11-6-4-5-10(9-11)13(15)12-7-2-3-8-14-12/h2-9H,1H3

Upstream product

• 109-04-6 2-bromo-pyridine 
• 19924-43-7 3-methoxyphenylacetonitrile 
• 782504-52-3 (3-methoxyphenyl)(pyridin-2-yl)methanol 
• 1121-60-4 pyridine-2-carbaldehyde 
• 2398-37-0 3-methoxyphenyl bromide 
• 109-06-8 α-picoline 
• 941279-81-8 2,4-dimethyl-3-(pyridin-2-ylmethyl)pentan-3-ol 
• 35854-44-5 2-(3-methoxybenzyl)pyridine 
• 100-70-9 2-Cyanopyridine 
• 2524-52-9 ethyl-2-picolinate 

Downstream Products

• 928046-33-7 1-(3-methoxyphenyl)-3-methyl-1-(2-pyridyl)-1-butanol 
• 95899-02-8 (3-methoxyphenyl)(pyridin-2-yl)methanamine 
• 1015447-07-0 (R)-3-methoxyphenyl(pyridin-2-yl)methanol 
• 782504-52-3 (3-methoxyphenyl)(pyridin-2-yl)methanol 
• 1015447-06-9 (S)-(3-methoxyphenyl)(pyridin-2-yl)methanol 
• 1214919-64-8 C₁₄H₁₄N₂O₂ 
• 928046-55-3 2-[1-(3-methoxyphenyl)-3-methyl-1-butenyl]pyridine 

Relevant articles and documents

Overcoming Electron-Withdrawing and Product-Inhibition Effects by Organocatalytic Aerobic Oxidation of Alkylpyridines and Related Alkylheteroarenes to Ketones

An organocatalyzed aerobic benzylic C-H oxidation of alkyl and aryl heterocycles has been developed. This transition metal-free method is able to overcome the electron-withdrawing effect as well as product-inhibition effects in heterobenzylic radical oxidation. A variety of ketones bearing N-heterocyclic groups could be prepared under relatively mild conditions with moderate to high yields.

Metal-Free Halogen(I) Catalysts for the Oxidation of Aryl(heteroaryl)methanes to Ketones or Esters: Selectivity Control by Halogen Bonding

Metal-free halogen(I) catalysts were used for the selective oxidation of aryl(heteroaryl)methanes [C(sp3)?H] to ketones [C(sp2)=O] or esters [C(sp3)?O]. The synthesis of ketones was performed with a catalytic amount of NBS in DMSO solvent. Experimental studies and density functional theory (DFT) calculations supported the formation of halogen bonding (XB) between the heteroarene and N-bromosuccinimide, which enabled imine–enamine tautomerism of the substrates. No additional activator was required for this crucial step. Isotope-labeling and other supporting experiments suggested that a Kornblum-type oxidation with DMSO and aerobic oxygenation with molecular oxygen took place simultaneously. A background XB-assisted electron transfer between the heteroarenes and halogen(I) catalysts was responsible for the formation of heterobenzylic radicals and, thus, the aerobic oxygenation. For selective acyloxylation (ester formation), a catalytic amount of iodine was employed with tert-butyl hydroperoxide in aliphatic carboxylic acid solvent. Several control reactions, spectroscopic studies, and Time-Dependent Density Functional Theory (TD–DFT) calculations established the presence of acetyl hypoiodite as an active halogen(I) species in the acetoxylation process. With the help of a selectivity study, for the first time we report that the strength of the XB interaction and the frontier orbital mixing between the substrates and acyl hypoiodites determined the extent of the background electron-transfer process and, thus, the selectivity of the reaction.

Direct oxidation of the Csp3–H bonds of N-heterocyclic compounds to give the corresponding ketones using a reusable heterogeneous MnOx-N@C catalyst

Novel reusable MnOx-N@C catalyst has been developed for the direct oxidation of N-heterocycles under solvent-free conditions using TBHP as benign oxidant to give the corresponding N-heterocyclic ketones. The catalytic system exhibited a broad substrate scope and excellent regioselectivity, as well as being amenable to gram-scale synthesis. This MnOx-N@C catalyst also showed good reusability and was successfully recycled six times without any significant loss of activity.