55096-85-0

Basic information

• Product Name: Benzenemethanamine,4-(dimethylamino)-N-(phenylmethyl)-
• Synonyms: Toluene-a,4-diamine, Na-benzyl-N4,N4-dimethyl- (6CI);4-(Dimethylamino)dibenzylamine
• CAS NO: 55096-85-0
• Molecular Formula: C₁₆H₂₀N₂
• Molecular Weight: 241.3508
• Mol File: 55096-85-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 369.5°C at 760 mmHg
• Flash Point: 146.2°C
• Appearance: /
• Density: 1.046±0.06 g/cm3(Predicted)
• Vapor Pressure: 1.18E-05mmHg at 25°C
• PKA: 9.33±0.20(Predicted)
• CAS DataBase Reference: Benzenemethanamine,4-(dimethylamino)-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine,4-(dimethylamino)-N-(phenylmethyl)-(55096-85-0)
• EPA Substance Registry System: Benzenemethanamine,4-(dimethylamino)-N-(phenylmethyl)-(55096-85-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 55096-85-0(Hazardous Substances Data)

Usage

General Description

Benzenemethanamine,4-(dimethylamino)-N-(phenylmethyl)-, also known by its common name, N,N-dimethyl-1-phenylmethanamine, is a chemical compound with a molecular formula C16H20N2. It is often used as a precursor in the production of pharmaceuticals, and as a reagent in the synthesis of organic compounds. Benzenemethanamine,4-(dimethylamino)-N-(phenylmethyl)- has a range of applications, including as an intermediate in the synthesis of medications such as vasopressors, local anesthetics, and antihypertensives. It is also used in the manufacturing of dyes and pigments, and as a corrosion inhibitor in various industries. Overall, Benzenemethanamine,4-(dimethylamino)-N-(phenylmethyl)- is a versatile and important chemical compound with various industrial uses.

InChI:InChI=1/C16H20N2/c1-18(2)16-10-8-15(9-11-16)13-17-12-14-6-4-3-5-7-14/h3-11,17H,12-13H2,1-2H3/p+1

Upstream product

• 100-52-7 benzaldehyde 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 100-46-9 benzylamine 
• 108191-13-5 N-benzyl-[4-(N,N-dimethylamino)]-benzamide 
• 1384953-85-8 C₂₀H₃₀N₂Si 
• 24431-17-2 N-(p-dimethylaminobenzylidene)benzylamine 

Downstream Products

• 55097-38-6 N¹-Benzyl-N¹-(4-dimethylamino-benzyl)-pentane-1,5-diamine 
• 101268-80-8 4-[(N-benzyl-hydrazino)-methyl]-N,N-dimethyl-aniline 
• 133102-34-8 benzyl-(4-dimethylamino-benzyl)-nitroso-amine 

Relevant articles and documents

Simple Metal-Free Direct Reductive Amination Using Hydrosilatrane to Form Secondary and Tertiary Amines

This work describes the use of cheap, safe, and easy-to-handle hydrosilatrane as the reductant in direct reductive amination reactions. This efficient method enables a facile, metal-free access to secondary and tertiary amines from a wide range of aldehydes and ketones, with the synthesis of tertiary amines requiring no additives at all. This reaction demonstrates excellent functional group tolerance, chemoselectivity, and scalability. (Figure presented.).

Heterogeneous Catalytic Reductive Amination of Carbonyl Compounds with Ni-Al Alloy in Water as Solvent and Hydrogen Source

The heterogeneous catalytic reductive amination of carbonyl compounds has been achieved by reactions of ammonium hydroxide and various amines with ketones and aldehydes. The process is based on the application of Raney type Ni-Al alloy in an aqueous medium. The reaction of the carbonyl compounds with the amine provided the corresponding Schiff bases that immediately underwent a reduction to provide primary and secondary amines as products. The controlled reaction of the Al content of the alloy with the solvent water generates hydrogen, and the in situ formed Raney Ni serves as a hydrogenation catalyst. The method is a simple and efficient way of preparing a broad variety of primary and secondary amines.

Trisubstituted sulfonamides: A new chemotype for development of potent and selective CB2 receptor inverse agonists

An extensive exploration of the structure-activity relationship of a trisubstituted sulfonamide series led to the identification of 39, which is a potent and selective CB2 receptor inverse agonist [K i(CB2) = 5.4 nM, and Ki(CB1) = 500 nM]. The functional properties measured by cAMP assays indicated that the selected compounds were CB2 inverse agonists with high potency values (for 34, EC50 = 8.2 nM, and for 39, EC50 = 2.5 nM). Furthermore, an osteoclastogenesis bioassay indicated that trisubstituted sulfonamide compounds showed great inhibition of osteoclast formation.