551-09-7Relevant articles and documents
Cystine cholesterol gel factor and preparation method thereof
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Paragraph 0040-0042, (2021/09/21)
The cystine cholesterol gel factor is obtained by taking natural product cholesterol and cystine as a raw material and carrying out chemical reaction. The invention also discloses a supramolecular gel which is prepared from the gel factors in benzene solvents. The micro-morphology is a regular nanobelt or nano fiber network structure in a solvent such as n-propanol or cyclohexane. Raw materials used in the preparation process of the gel factor and the supramolecular gel belong to natural small molecule compounds, and have the advantages of wide sources, good biocompatibility, unique structure and the like, and exhibit better ion selective recognition and reduction response characteristics. The gel system has good biocompatibility and environmental friendliness, provides a new idea for construction of the intelligent response gel material, and provides a new reference for expanding the application of the cystine and the cholesterol natural small molecule compound in the supermolecule field.
Synthesis of short and long-wavelength functionalised probes: amino acids' labelling and photophysical studies
Frade, Vania H.J.,Barros, Síria A.,Moura, Jo?o C.V.P.,Coutinho, Paulo J.G.,Gon?alves, M. Sameiro T.
, p. 12405 - 12418 (2008/03/13)
Fluorescent labelling of α-amino acids at their N or C terminals in the main and lateral chains at short and long wavelengths was carried out in different ways. The N-[3-(naphthalen-1-ylamino)propanoyl]amino acid methyl esters synthesised showed strong fluorescence in the visible region (～415 nm) of the electromagnetic spectrum. Condensation of these compounds with 5-diethylamino-2-nitrosophenol or 5-ethylamino-4-methyl-2-nitrosophenol produced the benzo[a]phenoxazine derivatives, with maximum emission wavelengths shifted to values higher than 644 nm. The synthesis of novel functionalised 5,9-diaminobenzo[a]phenoxazinium salts, by reaction of 5-ethylamino-4-methyl-2-nitrosophenol and N-substituted 1-naphthylamine and their use in the covalent labelling of the N or C terminals of valine, produced derivatives with long-wavelength emissions (644-653 nm). Photophysical studies using the synthesised compounds both in different solvents and in controlled pH were undertaken. Preliminary evaluation of photostability of the cationic polycyclic heterocycles in ethanol and water at physiological pH was also performed.
Chelating compounds and their use
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, (2008/06/13)
A chelating compound of the formula: wherein R is an aromatic ring-containing organic group, A is a residue of an aminopolyacetic acid excluding acetic acid groups (--CH2 COOH) therefrom, m is an integer of at least two and n is an integer of 1 or 2, or its salt, which has a specificity to a hepatobiliary system so that a complex formed between said chelating compound and a metallic element through a coordinate bond is useful and a diagnostic or therapeutic agent for hepatobiliary organs and tissues.
