5510-09-8

Basic information

• Product Name: 4-methyl-1-(naphthalen-1-ylsulfonyl)piperidine
• Synonyms: 4-Methyl-1-(1-naphthylsulfonyl)piperidine; 4-Methyl-1-(naphthalene-1-sulfonyl)-piperidine; piperidine, 4-methyl-1-(1-naphthalenylsulfonyl)-
• CAS NO: 5510-09-8
• Molecular Formula: C₈H₇NO₃S
• Molecular Weight: 289.3926
• Mol File: 5510-09-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 453.4°C at 760 mmHg
• Flash Point: 228°C
• Density: 1.211g/cm³
• Vapor Pressure: 2.08E-08mmHg at 25°C
• Refractive Index: 1.609
• CAS DataBase Reference: 4-methyl-1-(naphthalen-1-ylsulfonyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-1-(naphthalen-1-ylsulfonyl)piperidine(5510-09-8)
• EPA Substance Registry System: 4-methyl-1-(naphthalen-1-ylsulfonyl)piperidine(5510-09-8)

Safety Data

• Hazardous Substances Data: 5510-09-8(Hazardous Substances Data)

Upstream product

• 35511-14-9 methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide 
• 40506-05-6 1,1-dioxo-2-(2-oxo-propyl)-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one 
• 76508-40-2 (1,1,3-Trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-acetic acid phenyl ester 
• 76508-37-7 (1,1,3-Trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-acetic acid isopropyl ester 
• 76524-15-7 2-(Isopropoxycarbonylmethyl-sulfamoyl)-benzoic acid isopropyl ester 
• 76508-34-4 2-(Ethoxycarbonylmethyl-sulfamoyl)-benzoic acid ethyl ester 
• 76508-33-3 methyl 2- benzoate 
• 76508-35-5 isopropyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide 
• 128-44-9 saccharin sodium salt 
• 24683-20-3 ethyl 2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl) acetate 
• 6639-62-9 methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide 
• 66366-27-6 (1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-acetic acid tert-butyl ester 
• 81-07-2 saccharin 
• 24683-21-4 4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid ethyl ester 1,1-dioxide 

Downstream Products

• 35624-81-8 2-benzyl-2,3-dihydro-spiro[benzo[e][1,2]thiazine-4,2'-[1,3]dioxolane] 1,1-dioxide 
• 35511-16-1 2-benzyl-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[e][1,2]thiazin-4-one 
• 5510-10-1 2-methyl-2H-1,2-benzothiazine-4-(3H)-one-1,1-dioxyde 
• 600178-65-2 C₁₇H₁₆BrNO₄S 
• 651759-84-1 C₂₃H₂₁NO₄S 

Relevant articles and documents

Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes

Chalcones and 1,2-benzothiazines are two important classes of bioactive compounds, each scaffold endowed with diverse pharmacological activities. Combining both of these pharmacophores in a single molecule was aimed to yield multi-modal agents. Herein, we report a series of hybrid compounds 3a–3o derived from chalcones and 1,2-benzothiazine cores. They were synthesized from commercially available sodium saccharin, and the resulting 1,2-benzothiazine-derived ketone was then condensed with aromatic aldehydes in an aldol condensation to obtain the respective chalcones. The compounds were characterized using different analytical techniques including FT-IR, NMR spectroscopy, mass spectrometry and X-ray crystallography. Some synthesized chalcones revealed potent and/or selective inhibitory properties towards alkaline phosphatase isozymes transiently expressed in COS-7 cells. A detailed structure-activity and selectivity study was carried out with regard to the effect of different substituents at ortho-, meta- and para-positions of the phenyl residue. Compound 3c was the most effective human intestinal alkaline phosphatase (h-IAP) inhibitor (IC50 value of 1.04 μM), while it was not active against human tissue non-specific alkaline phosphatase (h-TNAP) isozyme. In contrast, 3i was a selective inhibitor of h-TNAP with IC50 values of 0.25 ± 0.01 μM. The possible binding interactions of the most effective inhibitors of h-TNAP and h-IAP were obtained from molecular docking studies.

4-hydroxy-3-benzoyl-2-alkyl -1,2-benzothiazine -1,1-dioxide derivatives of the (by machine translation)

The invention relates to a 4-hydroxy-3-benzoyl-2-alkyl -1,2-benzothiazine -1,1-dioxide derivatives, structural formula as (I). wherein: R 1 representative: C1-C5 alkyl; R 2 representative: 2-NO 2, 3-NO 2, 4-NO 2, 2-Br-4-Br, 2-Cl-3-Cl, 2-Cl-5-Cl, 2-Cl-4-F, 2-Cl-4-Br, 2-F-4-Cl, 2-Br-4-F, 2-Br-4-Cl, 2-Cl-4-NO 2, 2-Cl-4-CF 3, 4-SO 2 Me. To saccharines sodium salt as raw materials, by nucleophilic reaction, rearrangement Gabriel-Colman, decarboxylative, alkylation, condensation and Fries rearrangement reaction, the obtained 4-hydroxy-3-benzoyl-2-alkyl -1,2-benzothiazine -1,1-dioxide compound, and the herbicidal activity of the compound to the test, the results show that the compound has a good herbicidal activity, is a novel structure, application prospect of herbicides. (by machine translation)

NRF2 REGULATORS

The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.