55103-94-1Relevant articles and documents
Phosphites mediated decarboxylation of α-iminoacids. A straightforward route to labelled α-aminophosphates
Taran, Frederic,Doris, Eric,Noel, Jean-Pierre
, p. 287 - 295 (2007/10/03)
Aminophosphates are of great interest owing to their biological activity. These products are considered as structural analogues of the corresponding aminoacids but also as transition state mimics of peptide hydrolysis. They are known to act as antibiotic and pharmacological agents as well as enzyme inhibitors. Despite the growing importance of these drugs, few methods have been reported for their labelling. These isotopic syntheses usually involve strong bases to generate an α-carbanion which is then quenched with D2O. In the present article we would like to report two novel procedures for the one pot synthesis of labelled α-aminophosphates. These procedures could easily be adapted to tritium labelling.