5513-40-6Relevant articles and documents
Discovery of Modified Amidate (ProTide) Prodrugs of Tenofovir with Enhanced Antiviral Properties
Kal?ic, Filip,Zgarbová, Michala,Hodek, Jan,Chalupsky, Karel,Dra?ínsky, Martin,Dvo?áková, Alexandra,Strmeň, Timotej,?ebestík, Jaroslav,Baszczyňski, Ond?ej,Weber, Jan,Mertlíková-Kaiserová, Helena,Janeba, Zlatko
, p. 16425 - 16449 (2021/11/16)
This study describes the discovery of novel prodrugs bearing tyrosine derivatives instead of the phenol moiety present in FDA-approved tenofovir alafenamide fumarate (TAF). The synthesis was optimized to afford diastereomeric mixtures of novel prodrugs in
Synthesis method of O-[2]-[[tert-Butoxycarbonyl]amino]ethyl]-N-[fluorene methoxycarbonyl]-L-tyrosine
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Paragraph 0007; 0008, (2019/08/20)
The invention relates to a synthesis method of O-[2]-[[tert-Butoxycarbonyl]amino]ethyl]-N-[fluorene methoxycarbonyl]-L-tyrosine. The present invention mainly solves the technical problem of high scale-up production cost existing in the present synthesis m
Phosphylated tyrosine in albumin as a biomarker of exposure to organophosphorus nerve agents
Williams, Nichola H.,Harrison, John M.,Read, Robert W.,Black, Robin M.
, p. 627 - 639 (2008/03/13)
The organophosphorus nerve agents sarin, soman, cyclosarin and tabun phosphylate a tyrosine residue on albumin in human blood. These adducts may offer relatively long-lived biological markers of nerve agent exposure that do not 'age' rapidly, and which ar