5514-98-7

Basic information

• Product Name: tert-butyl 6-aminohexanoate
• Synonyms: tert-butyl 6-aminohexanoate;6-Aminohexanoic acid tert-butyl ester;tert-Butyl 6-aminocaproate
• CAS NO: 5514-98-7
• Molecular Formula: C₁₀H₂₁NO₂
• Molecular Weight: 187.28
• Mol File: 5514-98-7.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 74 °C(Press: 1 Torr)
• Appearance: /
• Density: 0.932±0.06 g/cm3(Predicted)
• PKA: 10.51±0.10(Predicted)
• CAS DataBase Reference: tert-butyl 6-aminohexanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 6-aminohexanoate(5514-98-7)
• EPA Substance Registry System: tert-butyl 6-aminohexanoate(5514-98-7)

Safety Data

• Hazardous Substances Data: 5514-98-7(Hazardous Substances Data)

Upstream product

• 158141-67-4 tert-butyl 6-(((benzyloxy)carbonyl)amino)hexanoate 
• 540-88-5 acetic acid tert-butyl ester 
• 60-32-2 6-aminohexanoic acid 
• 111-26-2 hexan-1-amine 
• 75-65-0 tert-butyl alcohol 
• 66678-88-4 6-amino-hexanoyl chloride 
• 1947-00-8 6-(benzyloxycarbonylamino)hexanoic acid 

Downstream Products

• 158141-61-8 N-<5-(tert-Butyloxycarbonyl)pentyl>-4,5-bis<(benzyloxycarbonyl)amino>valeramide 
• 114645-12-4 6-Benzoylamino-hexanoic acid tert-butyl ester 
• 114645-06-6 6-(Acetyl-benzoyloxy-amino)-hexanoic acid tert-butyl ester 
• 913625-15-7 6-(4-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-methoxycarbonyl-butyrylamino)-hexanoic acid tert-butyl ester 
• 1092975-97-7 tert-butyl 6-{[3-(4-methoxyphenyl)-2-phenylfuro[3,2-c]pyridin-4-yl]amino}hexanoate 
• 1092976-04-9 tert-Butyl 6-{[3-(4-ethylphenyl)-2-phenylfuro[2,3-b]pyridin-4-yl]amino}hexanoate 
• 1353744-96-3 C₃₅H₄₂N₂O₆ 
• 1353744-95-2 benzyl 2-(5-(tert-butoxycarbonyl)pentylamino)ethylcarbamate 
• 158141-63-0 N-<5-(tert-Butyloxycarbonyl)pentyl>-4,5-bisamino>valeramide 
• 158141-64-1 N-(5-Carboxypentyl)-4,5-bisamino>valeramide 
• 185426-28-2 6-(Benzyl-benzyloxycarbonylmethyl-amino)-hexanoic acid tert-butyl ester 

Relevant articles and documents

TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT

The present invention relates to a target protein degradation-inducing Degraducer, a preparation method thereof, and a pharmaceutical composition for preventing or treating diseases related to EED, EZH2, or PRC2 comprising same as an active ingredient. A novel compound represented by formula 1, according to the present invention is a Degraducer compound that induces degradation of a target protein, i.e., embryonic ectoderm development (EED) or polycomb repressive complex 2 (PRC2), utilizing cereblon E3 ubiquitin ligase, von Hippel-Lindau tumor suppressor (VHL) E3 ubiquitin ligase, mouse double minute 2 homolog (MDM2) E3 ubiquitin ligase, and cellular inhibitor of apoptosis protein 1 (cIAP) E3 ubiquitin ligase, wherein the compound has an aspect of remarkably achieving target protein degradation-inducing activity through a ubiquitin proteasome system (UPS), and therefore there is a useful effect in that it is possible to provide a pharmaceutical composition for preventing or treating diseases or conditions related to a target protein, and a functional health food composition for preventing or improving same, comprising said compound as an active ingredient.

Ozone-Mediated Amine Oxidation and Beyond: A Solvent-Free, Flow-Chemistry Approach

Ozone is a powerful oxidant, most commonly used for oxidation of alkenes to carbonyls. The synthetic utility of other ozone-mediated reactions is hindered by its high reactivity and propensity to overoxidize organic molecules, including most solvents. This challenge can largely be mitigated by adsorbing both substrate and ozone onto silica gel, providing a solvent-free oxidation method. In this manuscript, a flow-based packed bed reactor approach is described that provides exceptional control of reaction temperature and time to achieve improved control and chemoselectivity over this challenging transformation. A powerful method to oxidize primary amines into nitroalkanes is achieved. Examples of pyridine, C-H bond, and arene oxidations are also demonstrated, confirming the system is generalizable to diverse ozone-mediated processes.

A MedChem toolbox for cereblon-directed PROTACs

A modular chemistry toolbox was developed for cereblon-directed PROTACs. A variety of linkers was attached to a CRBN ligand via the 4-amino position of pomalidomide. We used linkers of different constitution to modulate physicochemical properties. We equipped one terminus of the linker with a set of functional groups, e.g. protected amines, protected carboxylic acids, alkynes, chloroalkanes, and protected alcohols, all of which are considered to be attractive for PROTAC design. We also highlight different opportunities for the expansion of the medicinal chemists' PROTAC toolbox towards heterobifunctional molecules, e.g. with biotin, fluorescent, hydrophobic and peptide tags.