55142-78-4

Basic information

• Product Name: Ticlopidine IMpurity D
• Synonyms: Ticlopidine IMpurity D
• CAS NO: 55142-78-4
• Molecular Formula: C₁₄H₁₅NS
• Molecular Weight: 229.3406
• Mol File: 55142-78-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 239-241 °C
• Boiling Point: 339.2±37.0 °C(Predicted)
• Appearance: /
• Density: 1.175±0.06 g/cm3(Predicted)
• PKA: 7.53±0.20(Predicted)
• CAS DataBase Reference: Ticlopidine IMpurity D(CAS DataBase Reference)
• NIST Chemistry Reference: Ticlopidine IMpurity D(55142-78-4)
• EPA Substance Registry System: Ticlopidine IMpurity D(55142-78-4)

Safety Data

• Hazardous Substances Data: 55142-78-4(Hazardous Substances Data)

Usage

Description

Ticlopidine Impurity D, also known as Deschloro Ticlopidine, is an impurity found in Ticlopidine (T438325), which is an antithrombotic agent and a platelet aggregation inhibitor. It is derived from the synthesis process of Ticlopidine and is characterized by the absence of a chlorine atom in its molecular structure.

Uses

Used in Pharmaceutical Industry:
Ticlopidine Impurity D is used as a reference standard for the identification, quality control, and purity assessment of Ticlopidine in the pharmaceutical industry. It helps ensure the safety and efficacy of the drug by providing a benchmark for comparison and analysis.
Used in Research and Development:
Ticlopidine Impurity D serves as an essential compound in the research and development of new antithrombotic agents and platelet aggregation inhibitors. It aids in understanding the structure-activity relationship, optimization of drug design, and the development of more effective and safer therapeutic alternatives.
Used in Regulatory Compliance:
Ticlopidine Impurity D is utilized in the regulatory compliance process to ensure that the manufacturing process of Ticlopidine meets the required standards and guidelines. It helps in monitoring and controlling the presence of impurities in the final drug product, thereby maintaining the quality and safety of the medication.

Upstream product

• 272-14-0 thieno[3,2-c]pyridine 
• 100-44-7 benzyl chloride 
• 54903-50-3 4,5,6,7-tetrahydrothieno[3,2-c]pyridine 
• 100-39-0 benzyl bromide 
• 100-52-7 benzaldehyde 
• 28783-41-7 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride 
• 137935-57-0 5-Benzyl-hexahydro-thieno[3,2-c]pyridine-3,7a-diol 

Downstream Products

• 150322-43-3 prasugel 
• 1400867-30-2 2-(2-fluorophenyl)-2-(2-methoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile 
• 150322-60-4 2-methoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine 
• 1400867-31-3 C₁₈H₁₈FNO₂S 
• 1056464-85-7 2-bromo-5-benzyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine 
• 1056464-86-8 2-methoxy-5-benzyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine 

Relevant articles and documents

Oxidative α-Trichloromethylation of Tertiary Amines: An Entry to α-Amino Acid Esters

α-Trichloromethylation of tertiary amines with trimethyl(trichloromethyl)silane by oxidative coupling, using DDQ as an oxidant, has been realized. The reaction is instantaneous, is scalable, and tolerates a broad range of functional groups and heteroarenes. The trichloromethylated products can be easily converted into β,β-dichloroamines, enamines, and α-amino acid esters under operationally simple conditions. This methodology provides an efficient alternative to the poisonous cyanation reactions for the synthesis of carboxylic acid and their derivatives.

Efficient synthesis of prasugrel, a novel P2Y12 receptor inhibitor

An efficient synthesis of prasugrel, a novel P2Y12 receptor inhibitor, is described. The cyclopropyl-phenylethanone intermediate was prepared by cyanide substitution, bromination, N-substitution, and the Grignard reaction. After acid hydrolyzation of the methyl ether and subsequent acetylation, the title product was obtained with a total yield of 21% after 10 linear steps from simple and commercially available raw materials.

Synthesis of thienopyridine and furopyridine derivatives of therapeutic interest

5-Benzyl-4,5,6,7-tetrahydrothieno [3,2-c] pyridines and analogous furopyridines were synthesized by NaBH4 reduction of the corresponding quaternary ammonium salts (method A). In the former series, the same derivatives were obtained by condensing benzyl halides with tetrahydrothienopyridine (method B).