55144-92-8

Basic information

• Product Name: 3-(2,4-DICHLOROPHENYL)PROPIONIC ACID
• Synonyms: 3-(2,4-DICHLOROPHENYL)PROPIONIC ACID;3-(2,4-DICHLOROPHENYL)PROPANOIC ACID;2,4-DICHLOROHYDROCINNAMIC ACID;3-(2,4-Dichlorophenyl)propionic acid,2,4-Dichlorohydrocinnamic acid;2,4-Dichloro-benzenepropanoic acid
• CAS NO: 55144-92-8
• Molecular Formula: C₉H₈Cl₂O₂
• Molecular Weight: 219.06
• Mol File: 55144-92-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 89-93 °C(lit.)
• Boiling Point: 336.6 °C at 760 mmHg
• Flash Point: 157.4 °C
• Appearance: /
• Density: 1.392 g/cm³
• Vapor Pressure: 4.33E-05mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.55±0.10(Predicted)
• CAS DataBase Reference: 3-(2,4-DICHLOROPHENYL)PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,4-DICHLOROPHENYL)PROPIONIC ACID(55144-92-8)
• EPA Substance Registry System: 3-(2,4-DICHLOROPHENYL)PROPIONIC ACID(55144-92-8)

Safety Data

• Hazard Codes: Xn,N,Xi
• Statements: 22-37/38-41-50/53
• Safety Statements: 26-36-60-61
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 55144-92-8(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C9H8Cl2O2/c10-7-3-1-6(8(11)5-7)2-4-9(12)13/h1,3,5H,2,4H2,(H,12,13)

Upstream product

• 1201-99-6 trans-2,4-dichlorocinnamic acid 
• 37885-41-9 2',4'-dichloropropiophenone 
• 61023-54-9 2-(2,4-dichloro-benzyl)-malonic acid diethyl ester 
• 69793-07-3 ethyl 3-(2,4-dichlorophenyl)propanoate 
• 1048340-02-8 3-(2,4-dichloro-phenyl)-propionic acid methyl ester 
• 82475-76-1 (E)-3-(2,4-dichlorophenyl)acrylic methyl ester 
• 20595-45-3 2,4-dichlorocinnamic acid 

Downstream Products

• 52397-82-7 3-(2,4-dichlorophenyl)propanoyl chloride 
• 448193-94-0 5,7-dichloro-2,3-dihydro-1H-inden-1-one 
• 1623130-92-6 (1H-1,2,4-triazol-1-yl)methyl 3-(2,4-dichlorophenyl)propanoate 
• 521098-40-8 (S)-3-(2,4-dichlorophenyl)-2-methylpropanoic acid 
• 521098-39-5 (R)-3-(2,4-dichlorophenyl)-2-methylpropanoic acid 
• 55144-55-3 2-bromo-4,6-dichloroindan-1-one 

Relevant articles and documents

Design and synthesis of a new polymer-supported Evans-type oxazolidinone: An efficient chiral auxiliary in the solid-ph ase asymmetric alkylation reactions

Wang resin-supported Evans' chiral auxiliary (23) was designed based on a novel polymer-anchoring strategy, which utilizes the 5-position of the oxazolidinone ring, and its new synthetic route applicable to multi-gram preparation in just a day was developed. Solid-phase Evans' asymmetric alkylation on 23-derived N-acylimide resin and following lithium hydroperoxide-mediated chemoselective hydrolysis afforded the corresponding α-branched carboxylic acids in desired high stereoselectivities (up to 97% ee) and moderate to good overall yield (up to 70%, for 3 steps), which were comparable to those of the conventional solution-phase methods. Furthermore, recovery and recycling of the polymer-supported chiral auxiliary were successfully achieved without decreasing the stereoselectivity of the product. Therefore, this is the first successful example that the solid-phase Evans' asymmetric enolate-alkylation was efficiently performed on the solid-support, and it is concluded that the connection to the solid-support via the 5-position of the oxazolidinone ring is an ideal strategy in the solid-phase Evans' chiral auxiliary.

Amide derivatives and their therapeutic use

A compound of formula (I), wherein R1 and R2 are independently selected from chloro, fluoro, bromo, C1-6 alkyl, C1-6 alkoxy or C1-6 haloalkyl provided that both R1 and R2 are not

Synthesis of derivatives of 2-imidazolyl-l-indanol and of 2-imidazolyl-l-tetralol with antifungal activity [(author's transl)]

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